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Formation of Dispersible Taohong Siwu Tablets
Published on: February 3, 2023
Overcoming poor tabletability of pharmaceutical crystals by surface modification.
Limin Shi1, Changquan Calvin Sun
1Department of Pharmaceutics, College of Pharmacy, University of Minnesota, 9-127B Weaver-Densford Hall, 308 Harvard Street S.E., Minneapolis, Minnesota 55455, USA. shilimin02@gmail.com
Pharmaceutical Research
|June 29, 2011
Summary
Coating acetaminophen particles with hydroxypropyl cellulose (HPC) via spray-drying significantly improved their tabletability. This particle coating strategy enhances the formulation of poorly compressible drugs.
Area of Science:
- Pharmaceutical Sciences
- Materials Science
Background:
- Poorly compressible drugs present formulation challenges.
- Improving tabletability is crucial for drug manufacturing.
Purpose of the Study:
- To evaluate the effectiveness of polymer coating on drug particles.
- To enhance the tabletability of poorly compressible acetaminophen.
Main Methods:
- Micronized acetaminophen was coated with hydroxypropyl cellulose (HPC) using spray-drying.
- Powder X-ray diffractometry, SEM, and thermal analysis were used for characterization.
- Tabletability was assessed using a compaction simulator and nanoindentation.
Main Results:
- Spray-drying successfully coated acetaminophen particles with HPC without altering acetaminophen's phase.
- Coated acetaminophen formed strong tablets (tensile strength 1.9-7.0 MPa) at 200 MPa.
- Tablet tensile strength increased with higher HPC coating percentages.
Conclusions:
- Hydroxypropyl cellulose coating significantly improves acetaminophen tabletability.
- Particle coating is a promising strategy for formulating poorly compressible drugs.
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