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Two sequential Tc-99m ECD SPECT studies in a case of sporadic Creutzfeldt-Jakob disease confirmed at autopsy
Barbara Paghera1, Federico Caobelli, Lutfun Nisa
1Nuclear Medicine Department, Brescia Hospital, University of Brescia, P.le Spedali Civili 1, Brescia, Italy.
Background:
Creutzfeldt-Jakob disease (CJD) is a subacute spongiform encephalopathy characterized by rapidly progressive dementia, hard to diagnose during life.
Materials And Methods:
We present a case of a patient with pathologically confirmed sporadic form of CJD in whom initial diagnostic tests were negative. Two sequential brain single-photon emission computed tomography with Tc-99m ethyl-cysteinate dimer were performed, the first one was performed few days after the admission into hospital and the second, 1 month later.
Results:
Both studies revealed a decrease in regional cerebral blood flow indicative of neuronal dysfunction, more pronounced in the second study.
Conclusion:
Current radionuclide scintigraphy can be an useful tool for the investigation of CJD.
