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Updated: May 31, 2026
05:16
Multiplexed Fluorescent Immunohistochemical Staining of Four Endometrial Immune Cell Types in Recurrent Miscarriage
Published on: August 4, 2021
Recurrent miscarriage
Kirsten Duckitt1, Aysha Qureshi
1Campbell River Hospital, Campbell River, BC, Canada.
BMJ Clinical Evidence
|July 2, 2011
Summary
This systematic review evaluates treatments for recurrent miscarriage, finding various interventions like low-dose aspirin and heparin plus aspirin effective for antiphospholipid syndrome. Effectiveness varies for unexplained recurrent miscarriage, highlighting the need for personalized treatment strategies.
Area of Science:
- Reproductive Medicine
- Clinical Gynecology
- Evidence-Based Medicine
Background:
- Recurrent miscarriage affects 1-2% of women, often with unknown causes.
- Successful subsequent pregnancy rates decrease with maternal age and miscarriage history.
- Antiphospholipid syndrome is identified in 15% of recurrent miscarriage cases.
Purpose of the Study:
- To systematically review treatments for unexplained recurrent miscarriage.
- To evaluate the effects of treatments for recurrent miscarriage caused by antiphospholipid syndrome.
Main Methods:
- Systematic review of 14 studies including systematic reviews, RCTs, and observational studies.
- Searched major databases (Medline, Embase, Cochrane Library) up to January 2010.
- Included harms alerts from regulatory agencies (FDA, MHRA).
Main Results:
- Evidence quality was assessed using GRADE methodology.
- Information on effectiveness and safety of multiple interventions was compiled.
- Specific treatments evaluated include aspirin, heparin, corticosteroids, and progesterone.
Conclusions:
- The review presents data on the effectiveness and safety of various interventions for recurrent miscarriage.
- Interventions discussed include low-dose aspirin, heparin plus low-dose aspirin, and progesterone.
- The findings aim to inform clinical decisions regarding recurrent miscarriage management.
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