Related Experiment Video
Updated: May 25, 2026

Herbs-Partitioned Moxibustion on the Navel in a Rat Model of Primary Dysmenorrhea with Cold Coagulation and Blood Stasis
Published on: October 4, 2024
Menorrhagia
Kirsten Duckitt1, Sally Collins
1Obstetrician and Gynaecologist, Campbell River and District General Hospital, Campbell River, Canada.
This systematic review evaluates medical and surgical treatments for heavy menstrual bleeding (menorrhagia). It found various interventions, including medications and surgical procedures, to manage this common gynecological condition.
Area of Science:
- Gynecology
- Reproductive Health
- Evidence-Based Medicine
Background:
- Menorrhagia significantly impacts women's daily activities and can lead to anemia.
- Potential causes include prostaglandin disorders, uterine fibroids, adenomyosis, and intrauterine device (IUD) use.
- A significant number of hysterectomies for menorrhagia are performed on uteri without apparent pathology.
Purpose of the Study:
- To systematically review the effects of medical treatments for menorrhagia.
- To systematically review the effects of surgical treatments for menorrhagia.
- To assess endometrial thinning prior to endometrial destruction for menorrhagia treatment.
Main Methods:
- Conducted a systematic review of literature up to June 2011.
- Searched major databases including Medline, Embase, and The Cochrane Library.
- Included harms alerts from regulatory agencies like the FDA and MHRA.
Main Results:
- Included 39 systematic reviews, randomized controlled trials (RCTs), and observational studies.
- Evaluated the quality of evidence for various interventions using the GRADE system.
- Identified information on the effectiveness and safety of numerous treatments.
Conclusions:
- Information on medical interventions such as combined pills, danazol, etamsylate, gonadorelin analogues, intrauterine progesterone, NSAIDs, and progestogens is presented.
- Information on surgical interventions including dilatation and curettage, endometrial destruction, and hysterectomy is presented.
- The review synthesizes evidence on the effectiveness and safety of these menorrhagia treatments.
Related Concept Videos
Menses Phase
When fertilization does not occur, the corpus luteum deteriorates, causing a significant drop in the levels of estrogen and progesterone in the body. This hormonal decrease triggers the release of prostaglandins, which cause the uterine...
Disorders of the Female Reproductive System
The Menstrual Cycle
The menstrual phase occurs from days 1 to 5 and involves the shedding of the stratum functionalis, as a uterine...
Hormonal Regulation of the Menstrual Cycle
At puberty, GnRH begins a pulsatile release pattern, which triggers the anterior pituitary gland to secrete follicle-stimulating hormone (FSH) and luteinizing hormone (LH). The frequency and amplitude of GnRH pulses vary across the menstrual cycle, with faster pulses favoring LH release and slower pulses favoring FSH release.
Cirrhosis I: Introduction
Esophageal Varices-II: Clinical Features and Management
In the initial assessment, a thorough review of the patient's medical history is vital to identify risk factors such as liver disease, alcohol abuse, or...
