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Related Concept Videos

Asthma I: Introduction01:28

Asthma I: Introduction

Asthma is a chronic inflammatory disorder of the airways characterized by variable airflow obstruction and heightened bronchial responsiveness to a wide range of triggers. The underlying inflammation leads to airway swelling, mucus hypersecretion, and smooth muscle constriction, all of which narrow the airway lumen and impede airflow. Clinically, asthma presents with recurrent episodes of wheezing, shortness of breath, chest tightness, and coughing, symptoms that typically vary in intensity and...
Asthma-III: Symptoms and Complications01:24

Asthma-III: Symptoms and Complications

Asthma, a common chronic respiratory condition, is classified considering the frequency and severity of symptoms alongside lung function impairment. Understanding this classification is essential for appropriate treatment and management. Here's a detailed look at the classification of asthma and its clinical features and complications:
Classification of Asthma
Asthma-I: Introduction01:29

Asthma-I: Introduction

Asthma is a chronic respiratory ailment that requires careful management due to its varying symptoms and influencing factors. It is characterized by airway inflammation, bronchial hyperresponsiveness, and reversible airflow obstruction, leading to symptoms like wheezing, shortness of breath, chest tightness, and coughing. The symptom frequency and intensity may vary considerably over time. It is also linked to immune system responses to allergens and irritants, highlighting the complex...
Asthma: Pathogenesis and Management01:20

Asthma: Pathogenesis and Management

Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
Asthma III: Clinical Manifestations01:13

Asthma III: Clinical Manifestations

Asthma presents with a characteristic pattern of episodic respiratory symptoms that reflect underlying airway inflammation, bronchoconstriction, and mucus hypersecretion. Although severity varies among individuals, certain clinical manifestations are considered hallmarks of the disorder and often guide diagnosis and assessment.Respiratory SymptomsA persistent cough is one of the most common early features of asthma. It is frequently dry and tends to worsen at night or in the early morning,...
Asthma-II: Pathophysiology and Classification01:26

Asthma-II: Pathophysiology and Classification

Asthma is a prevalent chronic respiratory condition marked by inflammation and hyperresponsiveness of the airways. Its pathophysiology involves complex interactions among inflammatory pathways, immune responses, and neural mechanisms.
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:

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Related Experiment Video

Updated: May 31, 2026

Bronchial Thermoplasty: A Novel Therapeutic Approach to Severe Asthma
14:39

Bronchial Thermoplasty: A Novel Therapeutic Approach to Severe Asthma

Published on: November 4, 2010

Asthma in adults.

Rodolfo J Dennis1, Ivan Solarte, Gustavo Rodrigo

  • 1Head, Departments of Medicine and Research, Fundacion Cardioinfantil Instituto de Cardiologia, Bogota, Colombia.

BMJ Clinical Evidence
|July 2, 2011
PubMed
Summary
This summary is machine-generated.

This review synthesizes evidence on asthma treatments. It covers interventions for acute exacerbations and chronic management, evaluating effectiveness and safety for severe and mild-to-moderate asthma.

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Murine Model of Allergen Induced Asthma
08:05

Murine Model of Allergen Induced Asthma

Published on: May 14, 2012

Related Experiment Videos

Last Updated: May 31, 2026

Bronchial Thermoplasty: A Novel Therapeutic Approach to Severe Asthma
14:39

Bronchial Thermoplasty: A Novel Therapeutic Approach to Severe Asthma

Published on: November 4, 2010

Murine Model of Allergen Induced Asthma
08:05

Murine Model of Allergen Induced Asthma

Published on: May 14, 2012

Area of Science:

  • Pulmonology
  • Clinical Pharmacology

Background:

  • Asthma affects 10% of adults, with 5% experiencing severe, treatment-resistant disease.
  • Severe asthma increases mortality risk; exacerbations pose risks for all asthma severity levels.
  • Current asthma management often relies on stepwise protocols, but this review focuses on evidence for specific interventions.

Purpose of the Study:

  • To systematically review the effects of various treatments for chronic asthma.
  • To evaluate the effectiveness and safety of interventions for acute asthma exacerbations.

Main Methods:

  • A systematic review of 99 studies, including systematic reviews, randomized controlled trials (RCTs), and observational studies.
  • Searched major databases (Medline, Embase, Cochrane Library) up to June 2008.
  • Included safety alerts from regulatory agencies like the FDA and MHRA.

Main Results:

  • Evaluated GRADE quality of evidence for numerous interventions.
  • Detailed findings on beta(2) agonists, corticosteroids (inhaled and oral), leukotriene antagonists, and theophylline for chronic asthma.
  • Summarized evidence for acute asthma treatments including oxygen, magnesium sulfate, heliox, and mechanical ventilation.

Conclusions:

  • Provides a comprehensive overview of evidence for acute and chronic asthma interventions.
  • Highlights the effectiveness and safety profiles of various pharmacological and non-pharmacological treatments.
  • Offers critical information for clinicians managing patients with diverse asthma severities.