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Updated: May 31, 2026

Single-molecule Manipulation of G-quadruplexes by Magnetic Tweezers
08:28

Single-molecule Manipulation of G-quadruplexes by Magnetic Tweezers

Published on: September 19, 2017

Methods for investigating G-quadruplex DNA/ligand interactions.

Pierre Murat1, Yashveer Singh, Eric Defrancq

  • 1Department of Chemistry, The University of Cambridge, Cambridge CB2 1EW, UK. pm473@cam.ac.uk

Chemical Society Reviews
|July 2, 2011
PubMed
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This summary is machine-generated.

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G-quadruplex DNA structures offer novel targets for cancer drug development. This review covers G-quadruplex ligands and biophysical methods for studying their interactions, crucial for advancing cancer therapies.

Area of Science:

  • Biochemistry
  • Molecular Biology
  • Medicinal Chemistry

Background:

  • Single-stranded DNA can form various structures, including G-quadruplexes.
  • G-quadruplexes are implicated in gene regulation and telomere maintenance, particularly in cancer.
  • These structures are promising targets for novel anti-cancer drug development.

Purpose of the Study:

  • To review G-quadruplex ligands and their development.
  • To provide an overview of biophysical techniques for monitoring G-quadruplex DNA/ligand interactions.

Main Methods:

  • Literature review of G-quadruplex ligands.
  • Overview of biophysical assays for G-quadruplex interaction studies.

Main Results:

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In Vitro Chemical Mapping of G-Quadruplex DNA Structures by Bis-3-Chloropiperidines
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Published on: May 12, 2023

Single-Molecule Fluorescence Visualization of DNA Polymerase Dynamics at G-Quadruplexes
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Related Experiment Videos

Last Updated: May 31, 2026

Single-molecule Manipulation of G-quadruplexes by Magnetic Tweezers
08:28

Single-molecule Manipulation of G-quadruplexes by Magnetic Tweezers

Published on: September 19, 2017

In Vitro Chemical Mapping of G-Quadruplex DNA Structures by Bis-3-Chloropiperidines
05:32

In Vitro Chemical Mapping of G-Quadruplex DNA Structures by Bis-3-Chloropiperidines

Published on: May 12, 2023

Single-Molecule Fluorescence Visualization of DNA Polymerase Dynamics at G-Quadruplexes
05:37

Single-Molecule Fluorescence Visualization of DNA Polymerase Dynamics at G-Quadruplexes

Published on: April 4, 2025

  • Numerous G-quadruplex ligands with varying affinities and selectivities have been developed.
  • A range of in vitro biophysical techniques exist to study these interactions.

    • Conclusions:

    • G-quadruplex structures are significant targets for drug design due to their role in cancer.
    • Efficient monitoring of G-quadruplex and ligand interactions is essential for developing effective therapeutics.