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Updated: May 31, 2026
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A Murine Model of Carotid Aneurysm Formation
Published on: September 9, 2025
A mouse model of intracranial aneurysm: technical considerations
Yoshiteru Tada1, Yasuhisa Kanematsu, Miyuki Kanematsu
1Department of Anesthesia and Perioperative Care, Center for Cerebrovascular Research, University of California, 1001, Potrero Avenue, No. 3C-38, San Francisco, CA 94110, USA.
Acta Neurochirurgica. Supplement
|July 5, 2011
Summary
A new mouse model effectively creates intracranial aneurysms using elastase injection. This model mimics human aneurysm pathology and is valuable for studying aneurysm development and potential treatments.
Area of Science:
- Neuroscience
- Cardiovascular Research
- Animal Models
Background:
- Intracranial aneurysms (IAs) pose significant health risks.
- Developing reliable animal models is crucial for understanding IA pathophysiology.
- Existing models may not fully recapitulate human IA characteristics.
Purpose of the Study:
- To establish and validate a novel mouse model for inducing intracranial aneurysms.
- To assess the efficacy and reproducibility of the induced aneurysm formation.
- To provide a platform for future research into IA pathogenesis and therapeutic interventions.
Main Methods:
- Hypertensive mice underwent stereotaxic injection of elastase into the cerebrospinal fluid at the right basal cistern.
- Aneurysm formation was induced and monitored over 3-4 weeks.
- Key pathological features were compared to human intracranial aneurysms.
Main Results:
- The model demonstrated a high incidence (60-80%) of large aneurysm formation within 3-4 weeks.
- Induced aneurysms exhibited pathological features consistent with human intracranial aneurysms.
- Technical factors, particularly precise needle placement, were identified as critical for success.
Conclusions:
- This elastase-induced mouse model is a simple and effective tool for studying intracranial aneurysms.
- The model recapitulates key aspects of human IA pathology.
- It serves as a valuable platform for investigating molecular mechanisms and testing therapeutic strategies in IA research.
