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Updated: May 31, 2026
07:32
Preparation and Characterization of Individual and Multi-drug Loaded Physically Entrapped Polymeric Micelles
Published on: August 28, 2015
Gastroretentive microparticles for drug delivery applications
Adeola Adebisi1, Barbara R Conway
1School of Applied Sciences, University of Huddersfield, Queensgate, Huddersfield HD1 3DH, UK.
Journal of Microencapsulation
|July 6, 2011
Summary
Gastroretention drug delivery uses microparticles to control release and prolong stomach residence. This approach minimizes transit time variability and offers potential for treating Helicobacter pylori infection.
Area of Science:
- Pharmaceutical Sciences
- Drug Delivery Systems
- Gastrointestinal Therapeutics
Background:
- Gastroretention strategies aim for controlled drug release and prolonged stomach residence.
- Challenges include variability in gastrointestinal transit times.
- Microparticulate systems offer a potential solution to minimize transit time variations.
Purpose of the Study:
- To review the role of microencapsulation in gastroretention drug delivery.
- To explore floating and mucoadhesive microparticles for enhanced drug delivery.
- To highlight the application of these systems in treating Helicobacter pylori infection.
Main Methods:
- Review of existing literature on gastroretention technologies.
- Focus on microencapsulation techniques for developing microparticles.
- Analysis of floating and mucoadhesive properties of microparticulate systems.
Main Results:
- Microencapsulation provides a viable strategy for gastroretention drug delivery.
- Floating and mucoadhesive microparticles demonstrate potential for controlled release.
- These systems show promise for the eradication of Helicobacter pylori.
Conclusions:
- Microencapsulation is a promising technology for gastroretention drug delivery.
- Floating and mucoadhesive microparticles can improve therapeutic outcomes.
- This approach holds significant clinical potential for treating widespread infections like H. pylori.
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