Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Menopause

Menopause

Menopause, a natural biological process marking the end of a woman's fertility, typically occurs between the fifth and sixth decade of life. This phase is characterized by the exhaustion of the ovarian follicle pool, leading to less responsive ovaries despite the high levels of Follicle Stimulating Hormone (FSH) and Luteinizing Hormone (LH). The consequential decrease in estrogen production results in symptoms like hot flashes, heavy sweating, headaches, hair loss, muscle pains, vaginal...

Disorders of the Female Reproductive System

Disorders of the Female Reproductive System

The female reproductive system can be affected by several disorders, including Premenstrual Syndrome (PMS), Premenstrual Dysphoric Disorder (PMDD), endometriosis, and various forms of cancer. PMS and PMDD are cyclical conditions that cause physical and emotional distress, with symptoms that include edema, mood swings, and food cravings. PMDD is a more severe form of PMS characterized by increased symptom severity that peaks during the luteal phase and tends to improve or resolve shortly after...

Microbiota of the Urogenital Tract

Microbiota of the Urogenital Tract

The human urogenital system, once thought to be sterile in healthy individuals, is now recognized as a complex microbial habitat. Advancements in molecular sequencing techniques have revealed that even in healthy adults, the kidneys and bladder harbor microbial populations similar to those found in the distal urethra, albeit in much lower abundance. These resident microorganisms, while generally innocuous, can become opportunistic pathogens under conditions that alter the urogenital...

Oogenesis

Oogenesis

In human women, oogenesis produces one mature egg cell or ovum for every precursor cell that enters meiosis. This process differs in two unique ways from the equivalent procedure of spermatogenesis in males. First, meiotic divisions during oogenesis are asymmetric, meaning that a large oocyte (containing most of the cytoplasm) and minor polar body are produced as a result of meiosis I, and again following meiosis II. Since only oocytes will go on to form embryos if fertilized, this unequal...

Physiology of Urine Formation

Physiology of Urine Formation

Urine formation is an essential function of the human body. It plays a critical role in maintaining homeostasis by regulating the volume and composition of body fluids. The kidneys, the primary organs involved in this process, filter blood to remove waste products and excess substances, ultimately producing urine.
Glomerular Filtration
The first stage in urine formation is glomerular filtration. Each kidney contains approximately 1 million nephrons, the functional units of filtration, with a...

Urodynamic Studies: Uroflowmetry

Urodynamic Studies: Uroflowmetry

Uroflowmetry is a non-invasive urodynamic test designed to measure various aspects of urination, including volume, flow rate, and the time to void. This test is crucial for diagnosing and assessing conditions such as bladder outlet obstruction, bladder dysfunction, incomplete bladder emptying, incontinence, and urinary tract blockages caused by benign prostatic hyperplasia (BPH) and urethral strictures.Pre-Test Instructions:Before a uroflowmetry test, patients are typically advised to drink...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Midurethral Sling vs OnabotulinumtoxinA in Females With Urinary Incontinence: The MUSA Randomized Clinical Trial.

JAMA·2025

Same author

Do We Need to Re-Focus on Functional Female Urethral Disorders in Lower Urinary Tract Dysfunction? ICI-RS 2024.

Neurourology and urodynamics·2024

Same author

Iltamiocel Autologous Cell Therapy for the Treatment of Female Stress Urinary Incontinence: A Double-Blind, Randomized, Stratified, Placebo-Controlled Trial.

Neurourology and urodynamics·2024

Same author

Do Prophylactic Postoperative Antibiotics Prevent Sacral Neuromodulation Infections?

Urogynecology (Philadelphia, Pa.)·2024

Same author

Trial Design for Mixed Urinary Incontinence: Midurethral Sling Versus Botulinum Toxin A.

Urogynecology (Philadelphia, Pa.)·2024

Same author

Temporally complex inflammatory networks in an animal model reveal signatures for interstitial cystitis and bladder pain syndrome phenotype.

Neurourology and urodynamics·2023

Search research articles

Related Experiment Video

Updated: May 31, 2026

An In Vivo Estrogen Deficiency Mouse Model for Screening Exogenous Estrogen Treatments of Cardiovascular Dysfunction After Menopause

An In Vivo Estrogen Deficiency Mouse Model for Screening Exogenous Estrogen Treatments of Cardiovascular Dysfunction After Menopause

Published on: August 13, 2019

Does estrogen have any real effect on voiding dysfunction in women?

Michelle E Koski¹, Christopher J Chermansky

¹Department of Urology, Louisiana State University Health Sciences Center New Orleans, 1542 Tulane Avenue, Room 547, New Orleans, LA 70112, USA.

Current Urology Reports

|July 7, 2011

Summary

Estrogen therapy for postmenopausal women

Area of Science:

Gynecology
Urology

Background:

Estrogen therapy has been a long-standing treatment for lower urinary tract dysfunction in postmenopausal women.
Evidence supporting its efficacy is varied and often debated.
Systemic estrogens have shown limited benefit for urinary incontinence in large studies.

Purpose of the Study:

To review the current literature on estrogen therapy for urinary incontinence, irritative voiding symptoms, and recurrent urinary tract infections in postmenopausal women.
To evaluate the comparative efficacy of systemic versus vaginal estrogen preparations.
To assess the role of estrogen in preventing recurrent urinary tract infections.

Main Methods:

Literature review of randomized controlled trials and meta-analyses.
Analysis of data from large multi-institutional studies.

More Related Videos

Estrogen-Like Effect of Bazi Bushen Capsule in Ovariectomized Rats

Estrogen-Like Effect of Bazi Bushen Capsule in Ovariectomized Rats

Published on: April 7, 2023

Protocol for Studying Extinction of Conditioned Fear in Naturally Cycling Female Rats

Protocol for Studying Extinction of Conditioned Fear in Naturally Cycling Female Rats

Published on: February 23, 2015

Related Experiment Videos

Last Updated: May 31, 2026

An In Vivo Estrogen Deficiency Mouse Model for Screening Exogenous Estrogen Treatments of Cardiovascular Dysfunction After Menopause

An In Vivo Estrogen Deficiency Mouse Model for Screening Exogenous Estrogen Treatments of Cardiovascular Dysfunction After Menopause

Published on: August 13, 2019

Estrogen-Like Effect of Bazi Bushen Capsule in Ovariectomized Rats

Estrogen-Like Effect of Bazi Bushen Capsule in Ovariectomized Rats

Published on: April 7, 2023

Protocol for Studying Extinction of Conditioned Fear in Naturally Cycling Female Rats

Protocol for Studying Extinction of Conditioned Fear in Naturally Cycling Female Rats

Published on: February 23, 2015

Synthesis of evidence regarding different estrogen formulations and delivery methods.

Main Results:

Systemic estrogens demonstrate minimal efficacy in treating urinary incontinence.
Vaginal estrogen preparations are superior to systemic estrogens for irritative voiding symptoms, despite study heterogeneity.
Randomized controlled trials support the use of estrogen for preventing recurrent urinary tract infections.

Conclusions:

The role of systemic estrogen in treating urinary incontinence remains limited.
Vaginal estrogen shows promise for irritative voiding symptoms, but further research is needed.
Estrogen therapy is supported by evidence for the prevention of recurrent urinary tract infections in postmenopausal women.