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Updated: May 31, 2026
09:49
A Whole Body Dosimetry Protocol for Peptide-Receptor Radionuclide Therapy (PRRT): 2D Planar Image and Hybrid 2D+3D SPECT/CT Image Methods
Published on: April 24, 2020
The Vienna protocol and perspectives in radionuclide therapy.
H Sinzinger1, B Palumbo, K Ozker
1Department of Nuclear Medicine, Medical University of Vienna, Vienna, Austria. helmut.sinzinger@chello.at
Summary
The Vienna protocol for samarium-153 ethylenediaminetetramethylenephosphonate (¹⁵³Sm-EDTMP) therapy offers pain relief and lesion regression. Early intervention upon detecting bone lesions or pain is recommended for optimal outcomes.
Area of Science:
- Nuclear medicine
- Oncology
- Radiopharmaceutical therapy
Background:
- The Vienna protocol for ¹⁵³Sm-EDTMP therapy has evolved over two decades.
- Repeated low-dose treatments aim to maximize therapeutic effects while minimizing hematological toxicity.
Purpose of the Study:
- To summarize the current Vienna protocol for ¹⁵³Sm-EDTMP therapy.
- To recommend optimal timing for treatment initiation.
- To highlight areas for future research and clinical trials.
Main Methods:
- Review of clinical experience and literature regarding ¹⁵³Sm-EDTMP therapy.
- Analysis of treatment outcomes, including pain palliation and lesion regression.
- Discussion of optimal treatment schedules and potential combination therapies.
Main Results:
- Significant benefits in pain palliation and some lesion regression are documented.
- ¹⁵³Sm-EDTMP treatment should commence upon detection of multiple bone lesions or pain.
- Lower doses with repeated administration may reduce hematological toxicity.
Conclusions:
- The Vienna protocol provides a basis for ¹⁵³Sm-EDTMP therapy, emphasizing early intervention.
- Prospective randomized controlled studies are needed to validate benefits beyond pain palliation.
- Further research should focus on treatment mechanisms, response predictors, and optimized therapeutic schedules.
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