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Acute generalized exanthematous pustulosis caused by diltiazem
Hyun-Je Kim1, Kyu-Dong Jung, Kyung-Tae Lee
1Department of Dermatology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
Annals of Dermatology
|July 9, 2011
Summary
Acute generalized exanthematous pustulosis (AGEP) is a rare drug-induced skin reaction. This case report details a patient who developed AGEP after taking diltiazem hydrochloride, a common hypertension medication.
Area of Science:
- Dermatology
- Pharmacology
Background:
- Acute generalized exanthematous pustulosis (AGEP) is a severe cutaneous adverse reaction.
- Drug hypersensitivity is the most common cause of AGEP.
Observation:
- A 51-year-old male presented with fever, pruritus, and an acute pustular eruption.
- The eruption resolved spontaneously after symptom onset.
Findings:
- Diltiazem hydrochloride, a calcium channel blocker used for hypertension and angina, was identified as the causative agent.
- This represents the first reported case of diltiazem-induced AGEP in Korean medical literature, adding to 9 previous English reports.
Implications:
- Highlights diltiazem hydrochloride as a potential trigger for AGEP.
- Emphasizes the importance of considering drug causality in AGEP diagnosis.
- Contributes to the global understanding of rare drug-induced skin reactions.
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