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Updated: May 31, 2026

A Magnetic Resonance Imaging-based Computational Protocol for Analysis of Plaque Morphology and Hemodynamics in Patients with Carotid Artery Stenosis
09:36

A Magnetic Resonance Imaging-based Computational Protocol for Analysis of Plaque Morphology and Hemodynamics in Patients with Carotid Artery Stenosis

Published on: August 12, 2025

Color Doppler ultrasonography and multislice computer tomography angiography in carotid plaque detection and

Viktorija Vucaj-Cirilović1, Milos Lucić, Kosta Petrović

  • 1Clinical Center of Vojvodina, Radiology Department, Novi Sad, Serbia. vcirilovic@hotmail.com

Vojnosanitetski Pregled
|July 12, 2011
PubMed

Insights

Color Doppler ultrasonography (CDU) and multislice computed tomography angiography (MSCTA) show similar accuracy for diagnosing extracranial carotid artery disease. CDU is recommended as the initial diagnostic tool due to its safety profile and comparable effectiveness.

Area of Science:

  • Vascular Surgery
  • Diagnostic Imaging
  • Neurology

Background:

  • Cerebrovascular diseases are a leading global cause of mortality.
  • Timely and precise diagnostics are crucial for managing these conditions.
  • Extracranial carotid artery disorders significantly impact patient outcomes.

Purpose of the Study:

  • To compare the diagnostic efficacy of Color Doppler ultrasonography (CDU) and multislice computed tomography angiography (MSCTA).
  • To evaluate the detection of morphological and functional disorders in the extracranial carotid arteries.
  • To assess plaque characteristics, stenosis degree, and intraplaque hemorrhage.

Main Methods:

  • Retrospective analysis of 75 patients (150 carotid arteries) examined between January 2008 and April 2009.
  • Sequential examination by CDU, followed by MSCTA.
  • Intraoperative findings and histopathological examination (in 10 patients) served as gold standards.
  • Analysis included plaque surface, structure, degree of stenosis, and intraplaque hemorrhage.

Main Results:

  • MSCTA demonstrated higher sensitivity than CDU in assessing plaque surface characteristics (e.g., ulcerations: CDU 54% vs. MSCTA 87%).
  • Both methods showed comparable results for plaque structure (correlation with HP: CDU 94% vs. MSCTA 96%) and localization (CDU 63% vs. MSCTA 65%).
  • Sensitivity and specificity for the degree of stenosis were similar, with no statistical difference (CDU 96% vs. MSCTA 98%).

Conclusions:

  • CDU and MSCTA exhibit similar sensitivity and specificity for evaluating plaque composition, degree of stenosis, and localization in extracranial carotid arteries.
  • CDU is a safe initial diagnostic method, avoiding the high radiation dose associated with MSCTA.
  • CDU is recommended as the first-line diagnostic tool in the algorithm for carotid artery disease assessment.
Abstract

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