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Updated: May 31, 2026
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Quantification of Atherosclerosis in Mice
Published on: June 12, 2019
LDL-based nanoparticles for contrast enhanced MRI of atheroplaques in mouse models
Yoko Yamakoshi1, Hui Qiao, Andrew N Lowell
1Laboratories of Molecular Imaging, Department of Radiology, University of Pennsylvania, 231 South 34th Street, Philadelphia, PA 19104-6323, USA. Yoko.Yamakoshi@uphs.upenn.edu
Chemical Communications (Cambridge, England)
|July 12, 2011
Abstract:
A LDL particle functionalized with a GdDO3A-monoamide chelate with a long alkenyl anchor (GdDO3A-OA) was prepared for in vivo detection of atheroplaques. The GdDO3A-OA, when successfully intercalated into the lipid layer of LDL particles, led to a significant enhancement of magnetic resonance imaging signal intensity of atheroplaques in atherosclerosis mouse models.
