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Related Concept Videos

Drug Abuse and Addiction: Pharmacological Phenomena01:15

Drug Abuse and Addiction: Pharmacological Phenomena

Drug dependence, abuse, and addiction are complex phenomena that can precipitate various abnormal states. Physical dependence refers to a state of pharmacological adaptation to a drug. This adaptation often results in tolerance—a reduced response to the drug after repeated administrations. When the drug use is abruptly stopped, withdrawal symptoms occur due to the body's need to readjust from the pharmacologically induced imbalance. However, tolerance and withdrawal symptoms do not necessarily...
Drug Dependence01:17

Drug Dependence

Medications are typically administered to achieve therapeutic effects. Some drugs can modify an individual's mood and perception, frequently resulting in various enjoyable experiences. However, this can result in drug dependency, a condition marked by continuous drug use despite potential negative consequences. Drug dependency primarily falls into two categories: psychological and physical dependence. Psychological dependence occurs when the pleasurable feelings induced by the drug...
Upper Respiratory Drugs: Antitussives, Expectorants, and Mucolytics01:23

Upper Respiratory Drugs: Antitussives, Expectorants, and Mucolytics

Respiratory symptoms, such as congestion and cough, commonly accompany respiratory tract conditions. Various medications, such as antitussives, expectorants, and mucolytics, play crucial roles in providing relief.
Antitussives include codeine, dextromethorphan (Robitussin), and benzonatate (Tessalon). Codeine and dextromethorphan exert their effects centrally by suppressing the cough reflex center in the medulla.  Benzonatate operates peripherally within the respiratory tract by anesthetizing...
Prescription, Nonprescription and Orphan Drugs01:02

Prescription, Nonprescription and Orphan Drugs

Prescription drugs require a prescription from a medical practitioner and can only be obtained from a pharmacy. They have many applications, including treating pain, anxiety, and hypertension.
The misuse and addiction to prescription drugs is a growing problem that can affect people of all age groups, specifically teenagers. This can happen when prescription medications are used in ways not intended by the prescriber, such as taking someone else's prescription or using medication for...
Toxidromes: Clinical Features01:30

Toxidromes: Clinical Features

Toxidromes are specific patterns of symptoms resulting from toxic substance exposure. They help in the identification and treatment of poisoning. The symptoms of each toxidrome group indicate poisoning by a certain class of chemicals or drugs.1. Sympathomimetic: Stimulates the sympathetic nervous system. Symptoms include agitation, increased heart rate (HR), blood pressure (BP), respiratory rate (RR), temperature, and pupil size. Drugs like cocaine and amphetamines, along with tremors and...
Drug Toxicity: Risk factors01:24

Drug Toxicity: Risk factors

Adverse Drug Reactions (ADRs) are potential complications that arise during pharmacotherapy, influenced by multiple risk factors. Age plays a significant role; both neonates and the elderly are at heightened risk due to their respective immature and diminished metabolic and elimination processes. Gender also impacts ADRs, with females experiencing a 1.5 to 1.7-fold greater risk than males, which may be linked to pharmacokinetic, pharmacodynamic, and hormonal differences. Notably, neonates, the...

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Color Spot Test As a Presumptive Tool for the Rapid Detection of Synthetic Cathinones
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Dextromethorphan abuse in Texas, 2000-2009.

Mathias B Forrester1

  • 1Environmental Epidemiology and Disease Registries Section, Texas Department of State Health Services, 1100 W 49th Street, Austin, TX 78756, USA. mathias.forrester@dshs.state.tx.us

Journal of Addictive Diseases
|July 13, 2011
PubMed
Summary

Dextromethorphan (DXM) abuse is a growing concern. Coricidin products were involved in over half of DXM misuse cases reported in Texas from 2000-2009, primarily affecting adolescents.

Area of Science:

  • Toxicology
  • Public Health

Background:

  • Dextromethorphan (DXM) is an over-the-counter cough suppressant.
  • Increasing intentional misuse and abuse of DXM-containing products present a public health challenge in the United States.

Purpose of the Study:

  • To identify and analyze intentional misuse or abuse ingestions of DXM-containing products reported to Texas poison centers between 2000 and 2009.
  • To determine the distribution of these ingestions based on various factors.

Main Methods:

  • Retrospective analysis of case data from Texas poison centers.
  • Inclusion criteria: intentional misuse or abuse ingestions of DXM-containing products.
  • Data collected on product involved, patient demographics, and outcomes.

Main Results:

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  • A total of 3,421 cases were identified.
  • Coricidin® products were implicated in 53.6% of cases.
  • The majority of patients were male (60.4%) and adolescents aged 13-19 (69.0%).
  • Potentially serious outcomes occurred in 46.2% of cases, with 83.1% requiring health care facility management.

Conclusions:

  • Dextromethorphan abuse, particularly involving Coricidin products, is a significant issue among adolescents in Texas.
  • The pattern of DXM abuse cases showed fluctuations over the decade.
  • A substantial proportion of DXM abuse ingestions lead to serious outcomes, necessitating medical intervention.