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Gas Chromatography-Mass Spectrometry-Based Targeted Metabolomics of Hard Coral Samples
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Bioactive cembrane-based diterpenoids from the soft coral Sinularia triangular.

Jui-Hsin Su1,2, Zhi-Hong Wen3

  • 1National Museum of Marine Biology & Aquarium, Pingtung 944,Taiwan.

Marine Drugs
|July 13, 2011
PubMed
Summary
This summary is machine-generated.

Researchers isolated two new cembrane diterpenoids from a Taiwanese soft coral, Sinularia triangularis. Some compounds showed cytotoxicity and anti-inflammatory effects, inhibiting key proteins in immune cells.

Keywords:
Sinularia triangularanti-inflammatorycytotoxicitysoft coral

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Area of Science:

  • Marine Natural Products Chemistry
  • Pharmacology
  • Immunology

Background:

  • Soft corals are a rich source of structurally diverse secondary metabolites.
  • Cembranolides, a class of diterpenoids, are known for their diverse biological activities.

Purpose of the Study:

  • To isolate and characterize cembrane-based diterpenoids from the Taiwanese soft coral Sinularia triangularis.
  • To evaluate the cytotoxic and anti-inflammatory potential of the isolated compounds.

Main Methods:

  • Chemical investigation using extensive spectroscopic analysis, including mass spectrometry and 2D NMR (COSY, HMQC, HMBC, NOESY).
  • Cytotoxicity assays against human tumor cell lines (CCRF-CEM and DLD-1).
  • In vitro anti-inflammatory assays using lipopolysaccharide-stimulated RAW264.7 macrophage cells.

Main Results:

  • Isolation of five cembrane-based diterpenoids (1-5), including two new metabolites, triangulenes A (1) and B (2).
  • Metabolites 3 and 5 demonstrated moderate cytotoxicity against CCRF-CEM and DLD-1 cell lines.
  • Compounds 3-5 exhibited significant in vitro anti-inflammatory activity by inhibiting inducible nitric oxide synthase (iNOS) protein expression.
  • Metabolites 4 and 5 effectively reduced cyclooxygenase-2 (COX-2) protein expression in macrophages.

Conclusions:

  • The study successfully identified novel cembrane diterpenoids from Sinularia triangularis.
  • The isolated compounds possess potential therapeutic applications due to their cytotoxic and anti-inflammatory properties.
  • Inhibition of iNOS and COX-2 suggests a role in modulating inflammatory pathways.