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Updated: May 31, 2026

Gas Chromatography-Mass Spectrometry-Based Targeted Metabolomics of Hard Coral Samples
Published on: October 13, 2023
Bioactive cembrane-based diterpenoids from the soft coral Sinularia triangular
Jui-Hsin Su1,2, Zhi-Hong Wen3
1National Museum of Marine Biology & Aquarium, Pingtung 944,Taiwan.
Abstract:
Chemical examination of the Taiwanese soft coral Sinularia triangular led to the isolation of five cembrane-based diterpenoids 1-5, including two new metabolites, triangulenes A (1) and B (2). The structures of the new metabolites were determined on the basis of extensive spectroscopic analysis, particularly mass spectroscopy and 2D NMR ((1)H-(1)H COSY, HMQC, HMBC, and NOESY) spectroscopy. Metabolites 3 and 5 exhibited moderate cytotoxicity to human tumor cell lines CCRF-CEM and DLD-1. Furthermore, 3-5 displayed significant in vitro anti-inflammatory activity in lipopolysaccharide-stimulated RAW264.7 macrophage cells by inhibiting the expression of the iNOS protein. Metabolites 4 and 5 also effectively reduced the expression of the COX-2 protein in the macrophages.
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