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The DNA Helix

The DNA Helix

Deoxyribonucleic acid, or DNA, is the genetic material responsible for passing traits from generation to generation in all organisms and most viruses. DNA is composed of two strands of nucleotides that wind around each other to form a spring-like structure called a double helix. However, the double helix is not perfectly symmetrical. Instead, there are regularly occurring grooves in the structure. The major groove occurs where the sugar-phosphate backbones are relatively far apart. This space...

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Updated: May 31, 2026

Self-assembly of Complex Two-dimensional Shapes from Single-stranded DNA Tiles

Self-assembly of Complex Two-dimensional Shapes from Single-stranded DNA Tiles

Published on: May 8, 2015

A facile, modular and high yield method to assemble three-dimensional DNA structures.

Christopher K McLaughlin¹, Graham D Hamblin, Faisal A Aldaye

¹Department of Chemistry, 801 Sherbrooke St. West, Montreal, QC, Canada H3A 2K6.

Chemical Communications (Cambridge, England)

|July 13, 2011

Summary

This summary is machine-generated.

Researchers developed a fast method to create custom DNA cages with specific shapes like triangular, rectangular, and pentagonal prisms. This DNA nanotechnology enables precise 3D nanostructure design and addressability.

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Last Updated: May 31, 2026

Self-assembly of Complex Two-dimensional Shapes from Single-stranded DNA Tiles

Self-assembly of Complex Two-dimensional Shapes from Single-stranded DNA Tiles

Published on: May 8, 2015

Automated Robotic Liquid Handling Assembly of Modular DNA Devices

Automated Robotic Liquid Handling Assembly of Modular DNA Devices

Published on: December 1, 2017

Design and Synthesis of a Reconfigurable DNA Accordion Rack

Design and Synthesis of a Reconfigurable DNA Accordion Rack

Published on: August 15, 2018

Area of Science:

DNA nanotechnology
Synthetic biology
Structural DNA self-assembly

Background:

DNA self-assembly offers a powerful platform for creating nanoscale structures.
Designing complex, addressable DNA nanostructures with precise geometries remains a challenge.

Purpose of the Study:

To present a rapid and quantitative method for generating DNA cages with designed geometries.
To demonstrate the creation of triangular, rectangular, and pentagonal prisms using this method.

Main Methods:

Utilizing a face-centered approach for 3D DNA construction.
Incorporating sequence uniqueness and symmetry in starting DNA strands.
Employing readily available starting DNA strands for cage synthesis.

Main Results:

Successfully generated DNA cages with specific geometric designs, including triangular (TP), rectangular (RP), and pentagonal prisms (PP).
The method is rapid and quantitative, allowing for efficient production of DNA nanostructures.
Achieved nanostructure addressability without compromising geometric design.

Conclusions:

The developed method provides a versatile approach for constructing geometrically defined DNA cages.
This technique facilitates the creation of addressable DNA nanostructures for various applications in nanotechnology.
The face-centered strategy offers a robust framework for advanced DNA self-assembly designs.