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Updated: May 31, 2026

A Customizable Approach for the Enzymatic Production and Purification of Diterpenoid Natural Products
Published on: October 4, 2019
Bioactive diterpenoid containing a reversible "spring-loaded" (E,Z)-dieneone Michael acceptor
Prasoon Gupta1, Upasana Sharma, Thomas C Schulz
1Department of Chemistry and Biochemistry, Florida Atlantic University, Boca Raton, Florida 33431, USA.
Abstract:
Three new briarane diterpenoids, briareolate esters L-N (1-3), have been isolated from a gorgonian Briareum asbestinum. Briareolate esters L (1) and M (2) are the first natural products possessing a 10-membered macrocyclic ring with a (E,Z)-dieneone and exhibit growth inhibition activity against both human embryonic stem cells (BG02) and a pancreatic cancer cell line (BxPC-3). Briareolate ester L (1) was found to contain a "spring-loaded" (E,Z)-dieneone Michael acceptor group that can form a reversible covalent bond to model sulfur-based nucleophiles.
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