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Related Concept Videos

Asthma I: Introduction01:28

Asthma I: Introduction

Asthma is a chronic inflammatory disorder of the airways characterized by variable airflow obstruction and heightened bronchial responsiveness to a wide range of triggers. The underlying inflammation leads to airway swelling, mucus hypersecretion, and smooth muscle constriction, all of which narrow the airway lumen and impede airflow. Clinically, asthma presents with recurrent episodes of wheezing, shortness of breath, chest tightness, and coughing, symptoms that typically vary in intensity and...
Asthma-III: Symptoms and Complications01:24

Asthma-III: Symptoms and Complications

Asthma, a common chronic respiratory condition, is classified considering the frequency and severity of symptoms alongside lung function impairment. Understanding this classification is essential for appropriate treatment and management. Here's a detailed look at the classification of asthma and its clinical features and complications:
Classification of Asthma
Asthma-I: Introduction01:29

Asthma-I: Introduction

Asthma is a chronic respiratory ailment that requires careful management due to its varying symptoms and influencing factors. It is characterized by airway inflammation, bronchial hyperresponsiveness, and reversible airflow obstruction, leading to symptoms like wheezing, shortness of breath, chest tightness, and coughing. The symptom frequency and intensity may vary considerably over time. It is also linked to immune system responses to allergens and irritants, highlighting the complex...
Asthma: Pathogenesis and Management01:20

Asthma: Pathogenesis and Management

Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
Asthma III: Clinical Manifestations01:13

Asthma III: Clinical Manifestations

Asthma presents with a characteristic pattern of episodic respiratory symptoms that reflect underlying airway inflammation, bronchoconstriction, and mucus hypersecretion. Although severity varies among individuals, certain clinical manifestations are considered hallmarks of the disorder and often guide diagnosis and assessment.Respiratory SymptomsA persistent cough is one of the most common early features of asthma. It is frequently dry and tends to worsen at night or in the early morning,...
Asthma-II: Pathophysiology and Classification01:26

Asthma-II: Pathophysiology and Classification

Asthma is a prevalent chronic respiratory condition marked by inflammation and hyperresponsiveness of the airways. Its pathophysiology involves complex interactions among inflammatory pathways, immune responses, and neural mechanisms.
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:

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Updated: May 31, 2026

Bronchial Thermoplasty: A Novel Therapeutic Approach to Severe Asthma
14:39

Bronchial Thermoplasty: A Novel Therapeutic Approach to Severe Asthma

Published on: November 4, 2010

Asthma in adults.

Rodolfo J Dennis1, Ivan Solarte, Gustavo Rodrigo

  • 1Department of Medicine and Research, Fundacion Cardioinfantil Instituto de Cardiologia, Bogota, Colombia.

BMJ Clinical Evidence
|July 14, 2011
PubMed
Summary
This summary is machine-generated.

This review examines evidence for asthma treatments, including inhaled corticosteroids and beta(2) agonists, to manage chronic asthma effectively. It highlights interventions for severe and mild-to-moderate asthma, aiding clinical decision-making.

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Murine Model of Allergen Induced Asthma
08:05

Murine Model of Allergen Induced Asthma

Published on: May 14, 2012

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Last Updated: May 31, 2026

Bronchial Thermoplasty: A Novel Therapeutic Approach to Severe Asthma
14:39

Bronchial Thermoplasty: A Novel Therapeutic Approach to Severe Asthma

Published on: November 4, 2010

Murine Model of Allergen Induced Asthma
08:05

Murine Model of Allergen Induced Asthma

Published on: May 14, 2012

Area of Science:

  • Pulmonology
  • Clinical Pharmacology
  • Evidence-Based Medicine

Background:

  • Asthma affects 10% of adults, with 5% experiencing severe, treatment-resistant disease.
  • Severe asthma increases mortality risk; mild-to-moderate asthma also carries exacerbation risks.
  • Current asthma management often follows stepwise protocols, but this review focuses on intervention evidence.

Purpose of the Study:

  • To systematically review the effects of various treatments for chronic asthma.
  • To evaluate the effectiveness and safety of specific asthma interventions.
  • To provide evidence supporting clinical decisions in asthma management.

Main Methods:

  • Systematic review of medical literature up to April 2010.
  • Searched Medline, Embase, The Cochrane Library, and other databases.
  • Included harms alerts from regulatory agencies like the FDA and MHRA.

Main Results:

  • 54 systematic reviews, RCTs, and observational studies were included.
  • GRADE evaluation was used to assess the quality of evidence for interventions.
  • Evidence on specific treatments like anti-IgE, beta(2) agonists, inhaled corticosteroids, leukotriene antagonists, and theophylline was synthesized.

Conclusions:

  • The review presents evidence on the effectiveness and safety of key asthma interventions.
  • Specific treatments discussed include anti-IgE, beta(2) agonists, inhaled corticosteroids, leukotriene antagonists, and theophylline.
  • Findings aim to inform treatment choices for patients with varying asthma severity.