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Updated: May 31, 2026
11:51
Facile Preparation of 4-Substituted Quinazoline Derivatives
Published on: February 15, 2016
4,4'-Oxybis{N-[(E)-quinolin-2-yl-methyl-idene]aniline}
Daoud Djamel1, Douadi Tahar, Haffar Djahida
1Laboratoire d'Électrochimie des Matériaux Moléculaires et Complexes (LEMMC), Département de Génie des Procèdes, Faculté de Technologie, Université FERHAT ABBAS - SETIF, 19000, Algeria.
Summary
A novel Schiff base compound, C(32)H(22)N(4)O, was synthesized. Its crystal structure reveals specific dihedral angles and intermolecular hydrogen bonding, offering insights into molecular assembly.
Area of Science:
- Organic Chemistry
- Crystallography
- Materials Science
Background:
- Schiff bases are versatile organic compounds with diverse applications.
- Understanding the structural properties of Schiff bases is crucial for designing new materials.
- 4,4'-diamino-diphenyl ether and 2-quinoline-carboxaldehyde are key precursors in Schiff base synthesis.
Purpose of the Study:
- To synthesize and characterize a novel Schiff base compound with the formula C(32)H(22)N(4)O.
- To elucidate the crystal structure of the synthesized Schiff base.
- To investigate the intermolecular interactions within the crystal lattice.
Main Methods:
- Chemical synthesis involving the reaction of 4,4'-diamino-diphenyl ether and 2-quinoline-carboxaldehyde.
- Single-crystal X-ray diffraction analysis to determine the molecular and crystal structure.
- Analysis of dihedral angles and hydrogen bonding patterns.
Main Results:
- Successful synthesis of the Schiff base compound C(32)H(22)N(4)O.
- The molecular structure comprises two 4-{N-[(E)-quinolin-2-yl-methyl-idene]amino}-phenyl units linked by an oxygen bridge.
- Significant dihedral angles of 53.81° (benzene rings) and 42.56° (quinoline systems) were observed.
- Intermolecular C-H⋯N hydrogen bonding was identified in the crystal structure.
Conclusions:
- The study successfully synthesized and structurally characterized a new Schiff base.
- The determined crystal structure provides valuable data on the molecule's conformation and packing.
- The presence of hydrogen bonding suggests potential for supramolecular assembly and material design.
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