Related Experiment Video
Updated: May 31, 2026
Diffusion Tensor Magnetic Resonance Imaging in the Analysis of Neurodegenerative Diseases
Published on: July 28, 2013
Primary progressive aphasia patients evaluated using diffusion tensor imaging and voxel based volumetry-preliminary
Fábio Pascotto de Oliveira1, Jaderson Costa da Costa, Sabine Possa Marroni
1HUSM, Santa Maria, RS, Brazil. fpascotto@hotmail.com
Unlabelled:
There are individuals who have a progressive language deficit without presenting cognitive deficits in other areas. One of the diseases related to this presentation is primary progressive aphasia (PPA).
Objective:
Identify by means of diffusion tensor imaging (DTI) and measurements of cortical volume, brain areas that lead to dysphasia when presenting signs of impaired connectivity or reduced volume.
Method:
Four patients with PPA were evaluated using DTI, and measurements of cortical volumes in temporal areas. These patients were compared with two normal volunteers.
Results:
There is a trend to a difference in the number and volume of related fibers between control group and patients with PPA. Comparing cortical volumes in temporal areas between groups yielded a trend to a smaller volume in PPA patients.
Conclusion:
Patients with PPA have a trend to impairment in cortical and subcortical levels regarding relevant areas.
