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Updated: May 31, 2026

Reconstitution of Basic Mitotic Spindles in Spherical Emulsion Droplets
Published on: August 13, 2016
Mitotic spindle orientation in asymmetric and symmetric cell divisions during animal development
Xavier Morin1, Yohanns Bellaïche
1Institut de Biologie de l'Ecole Normale Supérieure, 46 rue d'Ulm, Paris, France. xavier.morin@ens.fr
Abstract:
The orientation of the mitotic spindle has been proposed to control cell fate choices, tissue architecture, and tissue morphogenesis. Here, we review the mechanisms regulating the orientation of the axis of division and cell fate choices in classical models of asymmetric cell division. We then discuss the mechanisms of mitotic spindle orientation in symmetric cell divisions and its possible implications in tissue morphogenesis. Many recent studies show that future advances in the field of mitotic spindle orientation will arise from combinations of physical perturbation and modeling with classical genetics and developmental biology approaches.
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