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Updated: May 30, 2026
06:50
Computational Prediction of Amino Acid Preferences of Potentially Multispecific Peptide-Binding Domains Involved in Protein-Protein Interactions
Published on: January 26, 2024
Peptidic foldamers: ramping up diversity.
Tamás A Martinek1, Ferenc Fülöp
1Institute of Pharmaceutical Chemistry, University of Szeged, Eötvös u. 6, 6720 Szeged, Hungary.
Chemical Society Reviews
|July 20, 2011
Summary
This review explores non-natural folded polymers, or foldamers. Peptidic foldamers are highlighted for their diverse structures and applications in biology and nanomaterials.
Area of Science:
- Polymer Chemistry
- Supramolecular Chemistry
- Materials Science
Background:
- Foldamers are versatile non-natural polymers with tunable secondary structures.
- Peptidic foldamers are well-studied and have applications in biology and nanotechnology.
- Designing novel foldamer structures is a key area of research.
Purpose of the Study:
- To review recent advancements in foldamer design and building blocks.
- To discuss emerging principles in foldamer stereochemical patterning.
- To cover new developments in foldamer tertiary/quaternary structures and self-assembly.
Main Methods:
- Literature review of recent foldamer research (176 references).
- Analysis of diverse building blocks for foldamer synthesis.
- Examination of stereochemical patterning strategies.
Main Results:
- Foldamers exhibit diverse residue-controlled secondary structures.
- Applications span biological systems and nanostructured materials.
- Recent progress includes complex tertiary/quaternary structures and self-assembly.
Conclusions:
- Foldamer design is rapidly advancing with new building blocks and principles.
- Foldamers offer significant potential for biomimetic and materials science applications.
- Further research into foldamer self-assembly and complex structures is ongoing.
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