[Exacerbation of progressive scleroderma following roentgen therapy]

In a 38-year-old female patient suffering from progressive scleroderma and breast carcinoma the clinical features were exacerbated and became generalized after radiotherapy, and unfortunately regressed only transiently during aggressive polychemotherapy. Links between progressive scleroderma and carcinoma and the immune system are discussed. The risk of post-irradiation worsening of progressive scleroderma is pointed out.