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Updated: May 30, 2026

Pharmacologic Induction of Epidermal Melanin and Protection Against Sunburn in a Humanized Mouse Model
Published on: September 7, 2013
Nonsteroidal anti-inflammatory drugs and risk of melanoma
Joanne M Jeter1, Joseph D Bonner, Timothy M Johnson
1University of Michigan Cancer Center, 1500 East Medical Center, Ann Arbor, MI 48109, USA.
Abstract:
Because nonsteroidal anti-inflammatory drugs (NSAIDs) inhibit tumor growth in vitro, we investigated the association between NSAIDs and melanoma to determine if there was epidemiologic evidence of a chemopreventive effect from these medications. Three hundred twenty-seven subjects with incident melanoma and 119 melanoma-free controls completed a structured interview assessing melanoma risk factors. The unadjusted odds ratio (OR) for use of nonaspirin NSAIDs was 0.58 (95% CI 0.31-1.11), in a comparison of subjects with melanoma to controls. After adjustment for melanoma risk factors, the OR was 0.71 (95% CI 0.23-2.02). Aspirin users had an unadjusted OR of 0.85 (95% CI 0.45-1.69) and an adjusted OR of 1.45 (95% CI 0.44-4.74). In this pilot study, we found no evidence of a significant association between analgesic use and melanoma risk when potential confounders are assessed. Based on conflicting reports in the literature, meta-analysis may be appropriate.
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