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Boron phenylalanine and related impurities: HPLC analysis, stability profile and degradation pathways
Lindsay Dick1, Neil Dooley, Moira A Elliott
1Strathclyde Institute for Pharmacy and Biomedical Analysis, Robertson Building, University of Strathclyde, 161 Cathedral Street, Glasgow G4 0RE, United Kingdom.
Abstract:
Boron phenylalanine is one of the lead drug candidates in the field of Boron Neutron Capture Therapy. Its inherent low toxicity allows large doses to be administered, but this makes it important to identify, rationalise and quantify impurities. Here we report a chromatographic assay method, the conditions under which the parent compound is unstable, and the suggested degradation mechanisms.
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