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Related Concept Videos

Raman Spectroscopy: Overview01:20

Raman Spectroscopy: Overview

The underlying principle of Raman spectroscopy is based on the interaction between light and matter, specifically molecules' inelastic scattering of photons. When a monochromatic beam of light, typically from a laser source, interacts with a sample, most scattered light has the same frequency as the incident light. This is known as Rayleigh scattering.
However, a small fraction of the scattered light exhibits a frequency shift due to the exchange of energy between the incident photons and the...
Raman Spectroscopy Instrumentation: Overview01:26

Raman Spectroscopy Instrumentation: Overview

A conventional Raman spectrophotometer includes a laser source, a sample holding system, a wavelength selector, and a detector.
The monochromatic laser source, typically using visible or near-infrared radiation, generates a highly focused beam of light. This light interacts with the molecules of the sample, scattering some of the light. Liquid and gaseous samples are usually tested in ordinary glass capillaries, while solids can be analyzed as powders packed in capillaries or as potassium...

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Updated: May 30, 2026

Resonance Raman Spectroscopy of Extreme Nanowires and Other 1D Systems
07:44

Resonance Raman Spectroscopy of Extreme Nanowires and Other 1D Systems

Published on: April 28, 2016

Nanoscale structural analysis using tip-enhanced Raman spectroscopy.

Tanja Deckert-Gaudig1, Volker Deckert

  • 1IPHT-Institute of Photonic Technology, Albert-Einstein-Str. 9, D-07745 Jena, Germany.

Current Opinion in Chemical Biology
|July 22, 2011
PubMed
Summary
This summary is machine-generated.

Tip-enhanced Raman scattering (TERS) offers label-free, nanometer-scale analysis of biological samples. This technique identifies and maps molecules like DNA and proteins with high precision.

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Characterization of Nanocrystal Size Distribution using Raman Spectroscopy with a Multi-particle Phonon Confinement Model

Published on: August 22, 2015

Area of Science:

  • Biophysics
  • Chemical Physics
  • Materials Science

Background:

  • Tip-enhanced Raman scattering (TERS) integrates Raman spectroscopy, plasmonics, and scanning probe microscopy.
  • It provides label-free chemical analysis with high spatial resolution.
  • TERS overcomes the diffraction limit for nanoscale investigations.

Purpose of the Study:

  • To highlight the capabilities of TERS for biochemical interface analysis.
  • To demonstrate label-free molecular identification and localization at the nanoscale.
  • To showcase TERS applications in biological samples.

Main Methods:

  • Combining Raman spectroscopy for molecular specificity.
  • Utilizing plasmonic nanoparticles for signal enhancement.
  • Employing scanning probe microscopy for high-resolution imaging.

Main Results:

  • Achieved nanometer lateral resolution for biochemical investigations.
  • Enabled identification and localization of nucleobases, proteins, lipids, and carbohydrates.
  • Demonstrated TERS utility in diverse biological samples, including DNA and cell membranes.

Conclusions:

  • TERS is a powerful tool for label-free, high-resolution analysis of biochemical interfaces.
  • The technique allows for detailed structural differentiation of biological constituents.
  • TERS opens new avenues for studying complex biological systems at the nanoscale.