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An experimental assessment of cyanide challenge dose-response, time-course and recovery of indicative toxicity
A M Buzaleh1, E S Vazquez, A M Batlle
1Centro de Investigaciones sobre Porfirinas y Porfirias CONICET, Facultad de Ciencias Exactas y Naturales, University of Buenos Aires, Argentina.
General Pharmacology
|January 1, 1990
Abstract:
1. Several sub-lethal doses of cyanide were assayed with the aim of obtaining significant differences in the parameters studied. A dose of 4 mg/kg s.c. was selected. 2. Present studies were carried out to determine the time dependence of the effects produced by s.c. administration of a single dose of potassium cyanide as well as the recovery time of some of the toxicity indicative parameters. 3. It was found that cyanide effects continued for at least 3 days; after the parameters had recovered normal values.