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Updated: May 30, 2026

Production and Testing of Antimicrobial Peptides and Their Mimics
Published on: April 10, 2026
Non-hemolytic α-AApeptides as antimicrobial peptidomimetics
Shruti Padhee1, Yaogang Hu, Youhong Niu
1Department of Chemistry, University of South Florida, 4202 E. Fowler Ave, Tampa, FL 33620, USA.
Abstract:
We report a new class of peptide mimetics, α-AApeptides, that display broad-spectrum activity against both Gram-negative and Gram-positive bacteria and fungi. With non-hemolytic activity, resistance to protease hydrolysis, and easy sequence programmability, α-AApeptides may emerge as a novel class of antibiotics.
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