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Updated: May 30, 2026

Multimodality Diagnosis of Mesenteric Ischemia
Published on: July 21, 2023
Imaging evidence for renomegaly in patients with POEMS syndrome
Allison J Clapp1, Christine U Lee, Christina M Wood-Wentz
1Department of Radiology, Mayo Clinic, Rochester, MN 55905, USA.
Rationale And Objectives:
Organomegaly in POEMS syndrome generally refers to the liver, spleen, and lymph nodes. This study investigates whether there is a significant difference in kidney sizes in patients with POEMS compared to normal controls.
Materials And Methods:
Calculated kidney volumes from 77 patients with POEMS syndrome who had undergone imaging by computed tomography or magnetic resonance imaging were compared to frequency-matched controls. For the POEMS patients and the controls, the volume of each kidney was obtained from a three-dimensional segmentation algorithm. Univariate and multiple variable linear regression models were used to identify any differences in kidney size between normal and POEMS patients.
Results:
There was a univariate statistically significant association between disease state and the difference in kidney volume; having POEMS was associated with 16.3 cm(3) greater kidney volume difference compared to control patients, P < .001. Using a multiple variable model and after adjusting for age, sex, and the smaller kidney size, there was a statistically significant association between disease state and the difference in kidney volume; having POEMS was associated with 16.8 cm(3) greater kidney volume compared to control patients, P < .001. There was not an independent statistically significant association between age, sex, or volume of the smaller kidney and the difference in kidney volume.
Conclusion:
This confirms what is known or suspected clinically, that organomegaly in POEMS includes renomegaly.
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