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Serum cholesterol methodology: 100 years of development
1Department of Pathology and Laboratory Medicine, University of Cincinnati College of Medicine, OH 45267-0529.
Annals of Clinical and Laboratory Science
|January 1, 1990
Summary
Serum cholesterol testing is a key health screening. Advances in measurement and standardization over 100 years ensure reliable results for this important clinical analysis.
Area of Science:
- Clinical Chemistry
- Biomedical Measurement
- Public Health Screening
Background:
- Serum cholesterol measurement is a critical health screening test, representing the first clinical analysis of a serum compound.
- Significant advancements in measurement and standardization methodologies have occurred over the past century.
- These improvements are the result of collaborative efforts across clinical research, regulatory bodies, and industry.
Purpose of the Study:
- To outline the historical development and future directions of serum cholesterol measurement standardization.
- To identify key components crucial for the future consistency of serum cholesterol analysis.
Main Methods:
- Review of historical advancements in clinical chemistry and measurement science.
- Identification of foundational standards and reference methods for serum cholesterol analysis.
Main Results:
- Serum cholesterol testing has evolved significantly over 100 years.
- Future reliability hinges on specific standards and methods.
Conclusions:
- The future consistency of serum cholesterol measurement is dependent on established standards and reference methods.
- Key elements for future constancy include the National Bureau of Standards (NBS) pure cholesterol standard, NBS Definitive Isotope Dilution Mass Spectrography Method, Centers for Disease Control (CDC) Lipid Laboratory Reference Method, and the CDC National Reference System for Serum Cholesterol.