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[Detection and molecular characterization of human parechovirus (HPeV) in children with acute gastroenteritis]

Jie Li1, Qing Zhang, Zi-qian Xu

  • 1College of Public Health, Harbin Medical University, Harbin 150086, China.

Zhonghua Shi Yan He Lin Chuang Bing Du Xue Za Zhi = Zhonghua Shiyan He Linchuang Bingduxue Zazhi = Chinese Journal of Experimental and Clinical Virology
|July 28, 2011
PubMed

Insights

Human parechovirus (HPeV) was detected in 8.82% of young children with acute gastroenteritis. HPeV1 was the most common type, primarily affecting children over two years old during autumn.

Area of Science:

  • Virology
  • Pediatrics
  • Infectious Diseases

Context:

  • Acute gastroenteritis is a common illness in young children.
  • Human parechovirus (HPeV) is an emerging pathogen associated with various clinical manifestations, including gastroenteritis.
  • Limited epidemiological data exists for HPeV in certain regions, particularly concerning its prevalence in pediatric populations.

Purpose:

  • To investigate the prevalence and characteristics of Human parechovirus (HPeV) infections in children under five years old presenting with acute gastroenteritis.
  • To identify the types of HPeV circulating in the study population.
  • To understand the epidemiological patterns of HPeV in Jilin.

Summary:

  • Real-time PCR and nested RT-PCR were employed to detect and type HPeV in stool samples from 306 children.
  • HPeV was identified in 8.82% (27/306) of cases. Eleven strains were typed, with HPeV1 being predominant (9 strains), followed by single strains of HPeV2 and HPeV4.
  • Infections were most frequent in the autumn, peaking in July, and appeared more prevalent in children older than two years. Nucleotide identity ranged from 79% to 92% compared to reference strains.

Impact:

  • This study provides crucial epidemiological insights into HPeV infections in a pediatric cohort in Jilin.
  • Findings highlight the need for continued, large-scale surveillance to monitor HPeV trends and understand its public health impact.
  • The absence of HPeV3 detection warrants further investigation in broader geographical contexts.
Abstract

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