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Updated: May 30, 2026

Induction of Invasive Transitional Cell Bladder Carcinoma in Immune Intact Human MUC1 Transgenic Mice: A Model for Immunotherapy Development
Published on: October 30, 2013
[Two cases of bladder cancer with hereditary nonpolyposis colorectal cancer]
Tomohiro Kawaoka1, Yasushi Miyagawa, Masao Tsujihata
1The Department of Urology, Osaka University Graduate School of Medicine, Osaka, Japan.
Abstract:
Hereditary nonpolyposis colorectal cancer (HNPCC) is an autosomal dominant disorder characterized by an excess of extracolonic malignancies including those of the urinary tract. We report two cases of bladder tumor associated with HNPCC. The reported cases were compatible for Amsterdam criteria II for HNPCC. It is important to obtain a family history of cancer in patients with urothelial carcinoma. A patient with a strongly positive cancer history must be carefully examined for HNPCC and HNPCC associated cancers.
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