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DNA Microarrays

DNA Microarrays

Microarrays are high-throughput and relatively inexpensive assays that can be automated to analyze large quantities of data at a time. They are used in genome-wide studies to compare gene or protein expression under two varied conditions, such as healthy and diseased states. Microarrays consist of glass or silica slides on which probe molecules are covalently attached through surface functionalization. Most commonly, the slides are prepared through the chemisorption of silanes to silica...

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Updated: May 30, 2026

Fabrication of a Multiplexed Artificial Cellular MicroEnvironment Array

Fabrication of a Multiplexed Artificial Cellular MicroEnvironment Array

Published on: September 7, 2018

A resettable dynamic microarray device.

Kosuke Iwai¹, Wei-Heong Tan, Hirotaka Ishihara

¹Center for International Research on Micronano Mechatronics-CIRMM, Institute of Industrial Science-IIS, The University of Tokyo, Bunkyo, Japan.

Biomedical Microdevices

|July 30, 2011

Summary

This summary is machine-generated.

This study presents a reusable device that uses fluid flow to trap and release hundreds of microbeads in an array. The simple design allows for efficient trapping and release, enabling multiple experiments with a single device.

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Area of Science:

Microfluidics
Biotechnology
Materials Science

Background:

Microbead manipulation is crucial for various applications.
Existing methods for trapping and releasing beads can be complex or inefficient.

Purpose of the Study:

To develop a simple, reusable microfluidic device for efficient hydrodynamic trapping and release of microbeads.
To optimize the device design for arraying hundreds of microbeads.

Main Methods:

Design and fabrication of a microfluidic device with guiding pillars.
Hydrodynamic manipulation of 100 μm microbeads using flow control.
Analysis of bead path within the microchannel to optimize pillar design.

Main Results:

Successful hydrodynamic trapping of hundreds of 100 μm microbeads in an array.
Efficient release of trapped beads by reversing flow direction.
Demonstration of multiple trapping and release cycles using a single device.

Conclusions:

The developed device offers a simple, robust, and highly efficient method for microbead manipulation.
The reusable nature and ease of operation make it suitable for various experimental applications.
Optimized design enables precise arraying and controlled release of large numbers of microbeads.