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Updated: May 30, 2026

Formation of Dispersible Taohong Siwu Tablets
Published on: February 3, 2023
Formulation study for orally disintegrating tablet using partly pregelatinized starch binder.
Kazuki Mimura1, Ken Kanada, Shinya Uchida
1Department of Pharmacy Practice and Science, School of Pharmaceutical Sciences, University of Shizuoka, Japan.
Partly pregelatinized starch is an effective binder for orally disintegrating tablets, enhancing production in standard facilities. Binder selection significantly impacts tablet properties, crucial for successful oral dosage form development.
Area of Science:
- Pharmaceutical Technology
- Drug Delivery Systems
Background:
- Orally disintegrating tablets (ODTs) offer improved patient compliance.
- Manufacturing ODTs often requires specialized facilities, limiting industrial scale-up.
Purpose of the Study:
- To develop a formulation design for ODTs producible in standard solid dosage form facilities.
- To investigate the impact of binder type and concentration on ODT properties.
Main Methods:
- Evaluation of various binders, focusing on partly pregelatinized starch, in wet granulation for ODTs.
- Application of a central composite design to optimize corn starch and partly pregelatinized starch content.
- Analysis of granule size, compressibility, and disintegration characteristics using statistical software.
Main Results:
- Partly pregelatinized starch demonstrated suitability as both a binder and disintegrant in ODT formulations.
- The formulation design successfully predicted optimal binder levels for desired granule properties.
- Binder type and content were identified as critical factors influencing ODT performance.
Conclusions:
- ODTs can be designed for industrial-scale production using conventional equipment.
- Partly pregelatinized starch is a promising excipient for ODT formulation.
- Binder optimization is essential for achieving desired physicochemical and disintegration properties in ODTs.
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