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Related Experiment Video

Updated: May 30, 2026

A Plasma Sample Preparation for Mass Spectrometry using an Automated Workstation

A Plasma Sample Preparation for Mass Spectrometry using an Automated Workstation

Published on: April 24, 2020

The plasma contact system 2.0.

Coen Maas¹, Chris Oschatz, Thomas Renné

¹Department of Molecular Medicine and Surgery and Center for Molecular Medicine, Karolinska Institutet, Stockholm, Sweden.

Seminars in Thrombosis and Hemostasis

|August 2, 2011

Summary

This summary is machine-generated.

The contact system, crucial for blood clotting and inflammation, has identified key in vivo activators like misfolded proteins and polyphosphates. Understanding these activators clarifies their roles in health and disease.

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Area of Science:

Biochemistry and molecular biology
Immunology and inflammation
Cardiovascular research

Background:

The contact system is a protease cascade initiated by factor XII activation on cardiovascular cells.
It triggers procoagulant and proinflammatory responses through the intrinsic coagulation pathway and kallikrein-kinin system.
While its in vitro biochemistry is understood, in vivo activators and their disease relevance remain unclear.

Purpose of the Study:

To provide an overview of contact system activators.
To discuss their roles in both physiological and pathological conditions.
To highlight recent findings on in vivo activators.

Main Methods:

Review of recent experimental and clinical data.
Analysis of biochemical pathways involved in contact system activation.
Synthesis of information on known and newly identified activators.

Main Results:

Misfolded proteins, collagens, and polyphosphates have been identified as key in vivo contact system activators.
These activators link the contact system to various disease states.
The study consolidates understanding of these previously enigmatic factors.

Conclusions:

Recent discoveries have elucidated the long-sought in vivo activators of the contact system.
These activators (misfolded proteins, collagens, polyphosphates) are critical for understanding the system's role in health and disease.
Further research into these activators promises new therapeutic strategies.