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Related Concept Videos

Tumor Immunotherapy01:27

Tumor Immunotherapy

Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...
Cancer Therapies02:49

Cancer Therapies

Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
Skin Cancer01:30

Skin Cancer

Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
Cancer Vaccines01:30

Cancer Vaccines

Cancer treatment vaccines are a rapidly evolving field that offers a promising approach to immunotherapy. Unlike traditional vaccines that prevent diseases, cancer treatment vaccines are designed to treat existing cancers by stimulating the immune system to recognize and attack cancer cells.
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
Combination Therapies and Personalized Medicine02:50

Combination Therapies and Personalized Medicine

Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...

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Related Experiment Video

Updated: May 30, 2026

Experimental Melanoma Immunotherapy Model Using Tumor Vaccination with a Hematopoietic Cytokine
09:15

Experimental Melanoma Immunotherapy Model Using Tumor Vaccination with a Hematopoietic Cytokine

Published on: February 24, 2023

Immunotherapy for cutaneous malignancy.

Sherrif F Ibrahim1, Divya Sambandan, Désirée Ratner

  • 1Division of Dermatologic Surgery, Department of Dermatology, University of Rochester Medical Center, Rochester, New York 14623, USA. sherrif_ibrahim@urmc.rochester.edu

Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [Et Al.]
|August 3, 2011
PubMed
Summary

Immunotherapy shows promise for treating skin cancer, especially advanced melanoma. Recent advances in understanding the immune system and improved techniques are increasing response rates for cutaneous malignancy.

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Analysis of Human T Cell Activity in an Allogeneic Co-Culture Setting of Pre-Treated Tumor Cells
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Experimental Melanoma Immunotherapy Model Using Tumor Vaccination with a Hematopoietic Cytokine
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Potentiation of Anticancer Antibody Efficacy by Antineoplastic Drugs: Detection of Antibody-drug Synergism Using the Combination Index Equation
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Area of Science:

  • Dermatology and immunology
  • Cancer research
  • Therapeutic innovation

Background:

  • Immunotherapy for cutaneous malignancy involves immune system modulation for skin cancer treatment.
  • Early immunotherapy efforts faced challenges, but recent advances show response rates nearing 50% for metastatic melanoma.
  • Progress stems from a deeper understanding of immune system intricacies and laboratory techniques.

Purpose of the Study:

  • To review the skin immune system's role in host response to malignancy.
  • To discuss current immunotherapeutic techniques for cutaneous malignancy.

Main Methods:

  • Extensive PubMed literature search.
  • Utilized MeSH terms: "immunotherapy" and "skin cancer."

Main Results:

  • Despite initial low patient responses, immunotherapy is now a leading skin cancer therapeutic.
  • Scientific knowledge and clinical protocols have advanced immunotherapy, particularly for advanced melanoma.

Conclusions:

  • Current treatments for advanced cutaneous malignancies like melanoma have limited efficacy.
  • Immunotherapies offer novel treatment strategies, especially in combination therapies.
  • No significant commercial interests were declared by the authors.