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Related Concept Videos

Septins01:19

Septins

Septins are protein filaments forming the cytoskeleton along with the microtubules, microfilaments, intermediate filaments, and other accessory proteins. In 1971 while studying the cell division cycle in mutant Saccharomyces cerevisiae Harwell et al. first identified the septin-related genes playing a crucial role in yeast cytokinesis. Fluorescence microscopy revealed that these proteins localize at the budding neck as rings. These ring-like proteins were then named Septins by John Pringle, and...
Next-generation Sequencing03:00

Next-generation Sequencing

The first human genome sequencing project cost $2.7 billion and was declared complete in 2003, after 15 years of international cooperation and collaboration between several research teams and funding agencies. Today, with the advent of next-generation sequencing technologies, the cost and time of sequencing a human genome have dropped over 100 fold.
Next-Generation Sequencing Methods
Although all next-generation methods use different technologies, they all share a set of standard features.
Genomics02:02

Genomics

Genomics is the science of genomes: it is the study of all the genetic material of an organism. In humans, the genome consists of information carried in 23 pairs of chromosomes in the nucleus, as well as mitochondrial DNA. In genomics, both coding and non-coding DNA is sequenced and analyzed. Genomics allows a better understanding of all living things, their evolution, and their diversity. It has a myriad of uses: for example, to build phylogenetic trees, to improve productivity and...
RNA-seq03:21

RNA-seq

RNA sequencing, or RNA-Seq, is a high-throughput sequencing technology used to study the transcriptome of a cell. Transcriptomics helps to interpret the functional elements of a genome and identify the molecular constituents of an organism. Additionally, it also helps in understanding the development of an organism and the occurrence of diseases. 
Before the discovery of RNA-seq, microarray-based methods and Sanger sequencing were used for transcriptome analysis. However, while microarray-based...
Role of Septins01:02

Role of Septins

Septins are the recently discovered fourth major protein component of the cytoskeleton, along with microfilaments, microtubules, and intermediate filaments. These proteins can associate with other cytoskeletal filaments and carry out varied roles or can be free-floating in the cytoplasm.
Cellular Functions of Septins
Recent studies have revealed the multifaceted roles of septins in various cellular processes such as cytokinesis, ciliogenesis, and neurogenesis. Septins act as scaffolds and...

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Related Experiment Video

Updated: May 30, 2026

Novel Sequence Discovery by Subtractive Genomics
09:40

Novel Sequence Discovery by Subtractive Genomics

Published on: January 25, 2019

Septin genomics: a road less travelled.

S E Hilary Russell1, Peter A Hall

  • 1Centre for Cancer Research and Cell Biology, Queens University Belfast, Belfast, Northern Ireland, UK. seh.russell@qub.ac.uk

Biological Chemistry
|August 4, 2011
PubMed
Summary

The human septin gene family, comprising 13 genes, exhibits complex genomics and splicing, leading to diverse isoforms. Understanding these septin gene family members is crucial for insights into human biology and disease.

Area of Science:

  • Genetics
  • Molecular Biology
  • Cell Biology

Background:

  • Septins form a gene family with shared ancestry and functions.
  • 13 human septin genes (SEPT1-12, SEPT14) are currently identified.
  • SEPT13 is recognized as a SEPT7-related pseudogene.

Purpose of the Study:

  • To review current knowledge of the human septin gene family.
  • To identify areas of uncertainty within the septin gene family.
  • To emphasize the need for comprehensive understanding of septin genomics and transcriptomics.

Main Methods:

  • Literature review of human septin gene family.
  • Analysis of genomic and transcriptomic data.
  • Identification of septin isoforms and interactions.

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G2-seq: A High Throughput Sequencing-based Technique for Identifying Late Replicating Regions of the Genome

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Last Updated: May 30, 2026

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Novel Sequence Discovery by Subtractive Genomics

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Targeted Next-generation Sequencing and Bioinformatics Pipeline to Evaluate Genetic Determinants of Constitutional Disease

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Main Results:

  • The human septin family consists of 13 genes with complex genomic structures.
  • Extensive alternative splicing generates numerous septin isoforms.
  • Detailed understanding of transcripts and isoforms is limited for most septins.

Conclusions:

  • A thorough understanding of septin genomics, transcriptomics, and regulation is essential.
  • This knowledge is critical for deciphering septin biology and pathobiology.
  • Further research is needed to elucidate the full spectrum of septin diversity and function.