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Related Concept Videos

Computed Tomography01:10

Computed Tomography

Tomography refers to imaging by sections. Computed tomography (CT) is a non-invasive imaging technique that uses computers to analyze several cross-sectional X-rays to reveal minute details about structures in the body.
The technique was invented in the 1970s and is based on the principle that as X-rays pass through the body, they are absorbed or reflected at different levels. In the technique, a patient lies on a motorized platform while a computerized axial tomography (CAT) scanner rotates...
Imaging Studies III: Computed Tomography01:27

Imaging Studies III: Computed Tomography

DefinitionComputed Tomography (CT) of the genitourinary (GU) tract is a non-invasive imaging modality that utilizes X-rays and computer processing to generate detailed cross-sectional images of the urinary system, encompassing the kidneys, ureters, bladder, and adjacent structures such as the adrenal glands.PurposeCT scans of the GU tract serve several diagnostic and therapeutic purposes, including:Diagnosis of Urinary Tract Diseases: Detects kidney stones, tumors, cysts, and congenital...

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Updated: May 30, 2026

Near Infrared Optical Projection Tomography for Assessments of &beta;-cell Mass Distribution in Diabetes Research
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Optimal analysis method for dynamic contrast-enhanced diffuse optical tomography.

Michael Ghijsen1, Yuting Lin, Mitchell Hsing

  • 1Department of Radiological Sciences, John Tu and Thomas Yuen Center for Functional Onco-Imaging, University of California, Irvine, CA 92697, USA.

International Journal of Biomedical Imaging
|August 4, 2011
PubMed
Summary
This summary is machine-generated.

Diffuse Optical Tomography (DOT) shows poor resolution due to light scattering. Combining DOT with MRI structural information and dynamic contrast enhancement significantly improves imaging accuracy for potential breast cancer detection.

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Area of Science:

  • Biomedical optics
  • Medical imaging
  • Optical tomography

Background:

  • Diffuse Optical Tomography (DOT) is an optical imaging technique with clinical uses.
  • DOT suffers from poor spatial resolution and accuracy due to photon scattering in tissues.
  • Magnetic Resonance Imaging (MRI) provides high-resolution anatomical data that can enhance DOT.

Purpose of the Study:

  • To investigate and compare reconstruction methods for DOT and dynamic contrast-enhanced DOT (DCE-DOT).
  • To evaluate the impact of MR anatomical a priori information on DOT and DCE-DOT accuracy.
  • To assess performance for arbitrarily-shaped objects using phantom and animal studies.

Main Methods:

  • Utilized Diffuse Optical Tomography (DOT) and dynamic contrast-enhanced DOT (DCE-DOT).
  • Incorporated Magnetic Resonance Imaging (MRI) structural a priori information.
  • Compared various reconstruction algorithms and analysis approaches.
  • Conducted phantom and animal studies.

Main Results:

  • DCE-DOT combined with MR structural a priori information yielded superior image quality.
  • This combined approach significantly improved quantitative accuracy compared to DOT alone.
  • Demonstrated enhanced performance for arbitrarily-shaped objects.

Conclusions:

  • DCE-DOT integrated with MR structural information offers improved accuracy for optical imaging.
  • A combined MRI-DOT system shows promise for imaging Indocyanine Green (ICG) enhancement.
  • This approach is a potentially valuable tool for breast cancer imaging.