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Related Concept Videos

Clinical Trials: Overview01:11

Clinical Trials: Overview

Clinical development focuses on how the drug will interact with the human body and encompasses four key phases of clinical trials, each serving a specific purpose in assessing the safety and effectiveness of new drugs. These phases overlap and build upon one another. Phase I involves a small group of healthy volunteers (typically 20-80 individuals) or, in cases where significant toxicity is expected, patients with the targeted disease, such as cancer or AIDS. The volunteers are tested for...
Clinical Trials01:16

Clinical Trials

Clinical trials are prospective experimental studies conducted on humans to determine the safety and efficacy of treatments, drugs, diet methods, and medical devices. Using statistics in clinical trials enables researchers to derive reasonable and accurate conclusions from the collected data, allowing them to make wise decisions in uncertain situations. In medical research, statistical methods are crucial for preventing errors and bias.
There are four phases in a clinical trial. A phase one...
Methods of Documentation VI: Case Management Model01:15

Methods of Documentation VI: Case Management Model

The case management model is a multidisciplinary approach that involves healthcare professionals from diverse disciplines, such as physicians, nurses, therapists, social workers, and pharmacists, working collaboratively to address the various needs of patients. Each healthcare professional brings unique expertise and perspectives, contributing to a more comprehensive understanding of the patient's condition and tailoring treatment plans accordingly.
For example, a patient with a chronic illness...
Study Designs in Epidemiology01:20

Study Designs in Epidemiology

Epidemiological study designs are fundamental tools for investigating the distribution, determinants, and control of health conditions in populations. They help researchers understand the relationships between exposures and outcomes, and they broadly fall into two categories: "observational" and "experimental" studies.
Observational studies are those where the researcher does not intervene but rather observes natural variations. They include cross-sectional, cohort, and case-control studies.
Nursing Clinical Information System01:27

Nursing Clinical Information System

Nursing Clinical Information System (NCIS)
A Nursing Clinical Information System (NCIS) is a specialized type of healthcare information system tailored to meet the unique needs of nursing practice. It incorporates the principles of nursing informatics to streamline information management and improve the quality of care delivery.
Critical attributes of NCIS include:
Bioavailability Study Design: Healthy Subjects Versus Patients01:15

Bioavailability Study Design: Healthy Subjects Versus Patients

Bioavailability studies are essential for evaluating a drug's therapeutic efficacy and understanding its absorption patterns under various physiological conditions. Conducting such studies on target patient populations provides more relevant data by simulating real-world disease states. However, practical challenges often necessitate the use of young, healthy adult volunteers as study subjects.Patients may exhibit altered drug absorption patterns due to the effects of the disease itself,...

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Related Experiment Video

Updated: May 30, 2026

Implementation of a Real-Time Psychosis Risk Detection and Alerting System Based on Electronic Health Records using CogStack
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Implementing a low-cost web-based clinical trial management system for community studies: a case study.

John Geyer1, Kathleen Myers, Ann Vander Stoep

  • 1Seattle Children's Research Institute, Seattle Children's Hospital, Seattle, WA, USA.

Clinical Trials (London, England)
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PubMed
Summary

Customizable web tools enable multi-site clinical trials in remote areas, improving access for underserved populations. This approach facilitates efficient data collection and study management for pediatric ADHD treatment research.

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Area of Science:

  • Clinical Research Informatics
  • Digital Health
  • Telemedicine

Background:

  • Multi-site clinical trials face logistical challenges, often necessitating web-based support systems.
  • Numerous commercial, open-source, and proprietary web systems exist for clinical trial support.
  • New customizable web tools offer data collection and management solutions without requiring programming expertise.

Purpose of the Study:

  • To demonstrate the feasibility of using low-cost, configurable applications for a customized web-based system in a five-site randomized clinical trial.
  • To establish the efficacy of teleconferencing for delivering evidence-based treatment to children with attention-deficit hyperactivity disorder (ADHD).
  • To enable direct data entry by participants from their home communities via a developed database.

Main Methods:

  • Selection of cost-effective, user-friendly tools adaptable for data collection and study management.
  • Customization of selected applications for specific trial needs.
  • Implementation of a web-accessible database for participant access and data entry.

Main Results:

  • An online assessment application, web portal creator, and Access 2007 database were customized.
  • System features include appointment scheduling, secure online assessments, incentive issuance, and electronic document transmission.
  • Successfully used with 125 participants across 5 communities, collecting 536 assessment sets.

Conclusions:

  • New web applications enable user-friendly, efficient, and cost-effective multi-site clinical trials for investigators with limited programming experience.
  • These systems facilitate the inclusion of populations typically excluded from traditional research.
  • While full automation is not yet achieved, the system is suitable for single data source investigations like psychosocial questionnaires.