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Updated: May 30, 2026
10:06
Cell Type-specific Gene Expression Profiling in the Mouse Liver
Published on: September 17, 2019
Roles of FGF19 in liver metabolism
S Kir1, S A Kliewer, D J Mangelsdorf
1Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA.
Cold Spring Harbor Symposia on Quantitative Biology
|August 5, 2011
Summary
Fibroblast growth factor 19 (FGF19), an ileum-derived hormone, regulates bile acid, glucose, and protein metabolism. Its metabolic effects suggest potential therapeutic applications for diabetes.
Area of Science:
- Endocrinology
- Metabolic Regulation
- Hepatology
Background:
- Fibroblast growth factor 19 (FGF19) is an ileum-derived enterokine.
- FGF19 plays a crucial role in regulating bile acid and nutrient metabolism.
- It influences glucose and lipid metabolism, acting as a postprandial regulator of hepatic processes.
Purpose of the Study:
- To investigate the metabolic roles of FGF19.
- To compare FGF19's metabolic effects with those of insulin.
- To explore the therapeutic potential of FGF19 and its variants in treating metabolic diseases like diabetes.
Main Methods:
- Review of recent studies on FGF19's metabolic functions.
- Analysis of FGF19's effects on hepatic protein and glucose metabolism.
- Comparison of FGF19 and insulin signaling pathways.
Main Results:
- FGF19 regulates bile acid synthesis and gallbladder volume.
- Like insulin, FGF19 promotes protein and glycogen synthesis and suppresses gluconeogenesis.
- Unlike insulin, FGF19 does not stimulate lipogenesis, utilizing distinct cellular signaling pathways.
Conclusions:
- FGF19 exhibits significant beneficial effects on liver metabolism.
- The distinct metabolic profile of FGF19 differentiates it from insulin.
- FGF19 and its variants hold promise as potential therapeutic agents for diabetes treatment.
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