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Chemical-Induced Skin Carcinogenesis Model Using Dimethylbenz[a]Anthracene and 12-O-Tetradecanoyl Phorbol-13-Acetate (DMBA-TPA)
Published on: December 19, 2019
Basic concepts of inflammation and its role in carcinogenesis
Stephen G Maher1, John V Reynolds
1Department of Surgery, Institute of Molecular Medicine, Trinity College Dublin and St. James's Hospital, Dublin 8, Ireland. maherst@tcd.ie
Summary
Chronic inflammation drives cancer development by affecting tumor initiation, promotion, and progression. Immune system components and host genetics play key roles in this complex carcinogenic process.
Area of Science:
- Immunology
- Oncology
- Pathology
Background:
- Normal inflammatory responses are essential for host defense and tissue repair.
- Chronic inflammation is increasingly recognized as a significant factor in cancer development.
- The link between inflammation and cancer has been established over nearly 150 years.
Purpose of the Study:
- To discuss the fundamental mechanisms of normal inflammation in wound healing.
- To explore the association between inflammation and carcinogenesis across cancer development stages.
- To examine the roles of the immune system and host genetics in cancer risk.
Main Methods:
- Review of fundamental concepts and mechanisms of inflammation.
- Discussion of the inflammatory process in relation to wound healing.
- Analysis of the role of innate and adaptive immune effectors in carcinogenesis.
- Examination of host genetic influences on cancer risk.
Main Results:
- Normal inflammation is a self-limiting process vital for protection and repair.
- Chronic inflammation is a key driver of carcinogenesis.
- Immune effectors from both innate and adaptive systems contribute to cancer development.
- Host genetics can modify an individual's cancer risk.
Conclusions:
- Inflammation plays a dual role: protective in the short term, but carcinogenic when chronic.
- Understanding the immune mechanisms and genetic factors involved in inflammation-driven carcinogenesis is crucial.
- This chapter provides a comprehensive overview of inflammation's multifaceted role in cancer.
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