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Updated: May 30, 2026

Isolation of Primary Mouse Retinal Pigmented Epithelium Cells
Published on: November 4, 2022
Protein misfolding and retinal degeneration
Radouil Tzekov1, Linda Stein, Shalesh Kaushal
1Department of Ophthalmology, University of Massachusetts Medical School, Worcester, Massachusetts 01655, USA.
Abstract:
The retina is a highly complex and specialized organ that performs preliminary analysis of visual information. Composed of highly metabolically active tissue, the retina requires a precise and well-balanced means of maintaining its functional activity during extended periods of time. Maintenance and regulation of a vast array of different structural and functional proteins is required for normal function of the retina. This process is referred to as protein homeostasis and involves a variety of activities, including protein synthesis, folding, transport, degradation, elimination, and recycling. Deregulation of any of these activities can lead to malfunctioning of the retina, from subtle subclinical signs to severe retinal degenerative diseases leading to blindness. Examples of retinal degenerative diseases caused by disruption of protein homeostasis include retinitis pigmentosa and Stargardt's disease. A detailed discussion of the role of disruption in protein homeostasis in these and other retinal diseases is presented, followed by examples of some existing and potential treatments.
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