Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Video

Updated: May 30, 2026

In Vitro Characterization of the Electrophysiological Properties of Colonic Afferent Fibers in Rats
08:19

In Vitro Characterization of the Electrophysiological Properties of Colonic Afferent Fibers in Rats

Published on: September 27, 2017

Temporary sacral nerve stimulation alters rectal sensory function: a physiological study.

Mostafa R E Abdel-Halim1, James Crosbie, Alec Engledow

  • 1Department of Pelvic Floor and GI Physiology at University College London Hospital, London, United Kingdom.

Diseases of the Colon and Rectum
|August 10, 2011
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Healthcare professionals' perspectives on the implementation and purposefulness of a new alcohol recovery Navigator role in the North East of England - preliminary qualitative findings.

Public health in practice (Oxford, England)·2025
Same author

Building Connections and Striving to Build Better Futures: A Qualitative Interview Study of Alcohol Recovery Navigators' Practice in the North East of England, UK.

International journal of environmental research and public health·2025
Same author

Surgical experience and identification of errors in laparoscopic cholecystectomy.

The British journal of surgery·2023
Same author

Are preoperative CT variables associated with the success or failure of subsequent ventral hernia repair: nested case-control study.

European radiology·2022
Same author

A Systematic Review Examining the Experimental Methodology Behind In Vivo Testing of Hiatus Hernia and Diaphragmatic Hernia Mesh.

Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract·2021
Same author

The Use of Botulinum Toxin in Complex Hernia Surgery: Achieving a Sense of Closure.

Frontiers in surgery·2021
Same journal

Recurrence After Rectopexy: Insights From Magnetic Resonance Defecography.

Diseases of the colon and rectum·2026
Same journal

Risk of Metabolic Disease After Right- vs Left-Sided Colectomy for Colon Cancer: A Nationwide Cohort Study.

Diseases of the colon and rectum·2026
Same journal

Sexual Distress Is Common in Long Term Follow-up After Pelvic Pouch for Ulcerative Colitis: A Cross-Sectional Study.

Diseases of the colon and rectum·2026
Same journal

End-to-Side Ileocolonic Anastomosis after Ileocecectomy for Crohn's Disease is a Safe Option with Low Recurrence.

Diseases of the colon and rectum·2026
Same journal

Cost-Effectiveness of Pelvic Floor Reconstruction Using Biological Mesh After Extralevator Abdominoperineal resection for Rectal Cancer.

Diseases of the colon and rectum·2026
Same journal

Patient-Level Socioecological Comorbidities and Time to Initiation of Curative-Intent Treatment for Colorectal Cancer.

Diseases of the colon and rectum·2026
See all related articles

Sacral nerve stimulation for fecal incontinence improved rectal sensory function by increasing distension thresholds, without altering rectal compliance. This suggests an afferent-mediated mechanism, not dependent on sphincter integrity.

Area of Science:

  • Neuroscience
  • Gastroenterology
  • Urology

Background:

  • Sacral nerve stimulation (SNS) indications are expanding, yet its precise mechanism of action remains unclear.
  • Understanding SNS mechanisms is crucial for optimizing treatment for conditions like fecal incontinence.

Purpose of the Study:

  • To investigate the impact of temporary sacral nerve stimulation on rectal compliance and sensory function.
  • To explore potential mechanisms underlying the clinical effectiveness of SNS in fecal incontinence.

Main Methods:

  • A prospective study involving 23 patients with fecal incontinence undergoing temporary SNS.
  • Measurements included anal manometry, rectal compliance, rectal sensory thresholds (barostat), and mucosal blood flow before and after stimulation.
  • Clinical response was evaluated using bowel diaries and Wexner scores.

More Related Videos

Novel Surgical Rodent Model for Studying Neuroma Pain Treatment Options using Targeted Muscle Reinnervation Through the Saphenous Nerve
07:00

Novel Surgical Rodent Model for Studying Neuroma Pain Treatment Options using Targeted Muscle Reinnervation Through the Saphenous Nerve

Published on: November 14, 2025

In vitro Functional Characterization of Mouse Colorectal Afferent Endings
14:09

In vitro Functional Characterization of Mouse Colorectal Afferent Endings

Published on: January 21, 2015

Related Experiment Videos

Last Updated: May 30, 2026

In Vitro Characterization of the Electrophysiological Properties of Colonic Afferent Fibers in Rats
08:19

In Vitro Characterization of the Electrophysiological Properties of Colonic Afferent Fibers in Rats

Published on: September 27, 2017

Novel Surgical Rodent Model for Studying Neuroma Pain Treatment Options using Targeted Muscle Reinnervation Through the Saphenous Nerve
07:00

Novel Surgical Rodent Model for Studying Neuroma Pain Treatment Options using Targeted Muscle Reinnervation Through the Saphenous Nerve

Published on: November 14, 2025

In vitro Functional Characterization of Mouse Colorectal Afferent Endings
14:09

In vitro Functional Characterization of Mouse Colorectal Afferent Endings

Published on: January 21, 2015

Main Results:

  • 70% of patients showed a favorable clinical response to SNS.
  • SNS significantly increased rectal pressure thresholds for urge and maximal tolerance.
  • Rectal compliance and mucosal blood flow did not significantly change; however, anal squeeze pressures increased in both responders and non-responders.

Conclusions:

  • Temporary SNS does not alter rectal compliance but significantly modifies rectal distension thresholds.
  • The observed changes, independent of sphincter integrity, support an afferent-mediated mechanism for SNS.
  • Further long-term studies are warranted to fully elucidate the effects of SNS.