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Role of Skin in Vitamin D Synthesis

Role of Skin in Vitamin D Synthesis

The skin plays a crucial role in the synthesis of vitamin D, a vital nutrient for various physiological processes in the body. Vitamin D is unique because it can be synthesized in the skin through a series of chemical reactions triggered by exposure to ultraviolet B (UVB) radiation from sunlight.
The solar UV B rays (290-315 nm) are absorbed by the skin, and 7-dehydrocholesterol (provitamin D3) photolyzes it to previtamin D3, which undergoes a rapid transformation to vitamin D3(cholecalciferol).

Skin Cancer

Skin Cancer

Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...

Mutations

Mutations

Mutations are changes in the sequence of DNA. These changes can occur spontaneously or they can be induced by exposure to environmental factors. Mutations can be characterized in a number of different ways: whether and how they alter the amino acid sequence of the protein, whether they occur over a small or large area of DNA, and whether they occur in somatic cells or germline cells.
Chromosomal Alterations Are Large-Scale Mutations
While point mutations are changes in a single nucleotide in...

Pigmentation

Pigmentation

The color of the skin is influenced by a number of pigments, including melanin, carotene, and hemoglobin. Recall that melanin is produced by cells called melanocytes, which are found scattered throughout the stratum basale of the epidermis. The melanin is transferred to the keratinocytes via melanosomes.
Melanin occurs in two primary forms: eumelanin that provides black and brown pigment and pheomelanin that provides red color. Dark-skinned individuals produce more melanin than those with pale...

Increased Body Temperature

Increased Body Temperature

A body temperature above 38°C (100.4 °F) is known as fever or pyrexia, and a person with fever is termed 'febrile.' Typically, the hypothalamus, a part of the brain that acts as the body's thermostat, regulates body temperature through a thermoregulatory setpoint. It receives signals from cold and warm thermal receptors throughout the body and adjusts the body's temperature accordingly. Fever occurs when this hypothalamic setpoint is altered, usually in response to an infection or illness.

Bulk Modulus

Bulk Modulus

The bulk modulus is a scientific term used to describe a material's resistance to uniform compression. It is the proportionality constant that links a change in pressure to the resulting relative volume change.

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Related Experiment Video

Updated: May 30, 2026

Pharmacologic Induction of Epidermal Melanin and Protection Against Sunburn in a Humanized Mouse Model

Pharmacologic Induction of Epidermal Melanin and Protection Against Sunburn in a Humanized Mouse Model

Published on: September 7, 2013

[Moderation is best also in sunbathing].

Matti Hannuksela

Duodecim; Laaketieteellinen Aikakauskirja

|August 13, 2011

Summary

This summary is machine-generated.

Solar ultraviolet radiation (UVR) has more documented disadvantages than benefits, with research focusing on skin cancer and aging. However, UVR also exhibits anti-inflammatory and anticancer properties, which are less explored but significant areas of study.

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Last Updated: May 30, 2026

Pharmacologic Induction of Epidermal Melanin and Protection Against Sunburn in a Humanized Mouse Model

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Published on: September 7, 2013

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Published on: May 28, 2013

Studying Chronic Exposure of Mice to Ultraviolet B Radiation

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Published on: August 19, 2025

Area of Science:

Dermatology
Photobiology
Oncology

Context:

Extensive research exists on the detrimental effects of solar ultraviolet radiation (UVR), primarily focusing on skin cancer and aging.
Limited attention has been given to the beneficial aspects of UVR, such as its anti-inflammatory and anticancer properties.

Purpose:

To highlight the under-researched anti-inflammatory and anticancer benefits of solar ultraviolet radiation.
To shift focus towards the positive biological activities of UVR, complementing existing research on its negative impacts.

Summary:

Solar UVR is predominantly discussed for its adverse effects like melanoma, skin cancers, and aging.
Emerging research indicates significant anti-inflammatory and anticancer activities associated with UVR exposure.
Current research trends include sunscreens, antioxidants for sunburn prevention, and urocanic acid, a natural anti-inflammatory agent in the skin.

Impact:

This research can lead to a more balanced understanding of UVR's role in human health.
It may pave the way for novel therapeutic strategies utilizing UVR's beneficial properties.
Further investigation into UVR's anti-inflammatory and anticancer mechanisms could offer new avenues for disease prevention and treatment.