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Updated: May 30, 2026

Protocol for the Synthesis of Ortho-trifluoromethoxylated Aniline Derivatives
Published on: January 19, 2016
2-Amino-3,4,5,6-tetra-fluoro-benzoic acid
Xiao-Jian Liao1, Wei Guo, Shi-Hai Xu
1Department of Chemistry, Jinan University, Guangzhou 510632, People's Republic of China.
Abstract:
The asymmetric unit of the title compound, C(7)H(3)F(4)NO(2), obtained as an inter-mediate in the synthesis of a coupling reagent, contains four independent and conformationally similar mol-ecules. The amine H atoms form both intra-molecular and inter-molecular N-H⋯O(carbox-yl) hydrogen bonds which, together with inter-molecular O-H⋯O(carbox-yl) hydrogen bonds and N-H⋯F associations form ribbon structures along the a axis.
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