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Related Concept Videos

Secondary Lymphoid Organs01:15

Secondary Lymphoid Organs

Secondary organs, including lymph nodes, the spleen, and mucosa-associated lymphoid tissue (MALT), work harmoniously to protect us from disease and infection.
The spleen is a vital organ in the lymphatic system, nestled in the upper left side of the abdomen. It is composed of two primary regions: the red pulp and the white pulp, each having distinct functions. The red pulp performs a significant role in blood filtration. It efficiently purges the blood of old or damaged red blood cells and...
Primary Lymphoid Organs01:16

Primary Lymphoid Organs

Primary lymphoid organs are pivotal in the formation, development, and maturation of lymphocytes, the white blood cells that serve as the backbone of our immune system. This crucial function underscores their fundamental role in maintaining our overall health and immunity. The two primary lymphoid organs of prime importance are the red bone marrow and the thymus.
The red bone marrow is a soft, spongy tissue nestled in the interior of long bones such as the humerus and femur. It is the site...
Lymphoid Cells and Tissues01:18

Lymphoid Cells and Tissues

Lymphoid cells and tissues are integral to the immune system, which is crucial in maintaining our body's defense against harmful pathogens. They form the building blocks of lymphoid organs, which include the spleen, thymus, and lymph nodes.
Lymphoid cells consist of various types of immune system cells. These include B and T lymphocytes, which are responsible for producing antibodies and killing infected cells, respectively. Dendritic cells act as messengers between the innate and adaptive...
Detailed Structure and Function of Lymph Nodes01:23

Detailed Structure and Function of Lymph Nodes

Lymph nodes are bean-shaped structures that cluster along the lymphatic vessels in the inguinal, axillary, and cervical regions. Each node is divided into compartments by a capsule that extends trabeculae inward.
From a histological perspective, lymph nodes can be split into two main areas: the superficial cortex and the deep medulla. The outer cortex is populated by dendritic cells, macrophages, and B lymphocytes, which are densely packed into follicles. When these B-lymphocytes are presented...

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Tumor Engraftment in a Xenograft Mouse Model of Human Mantle Cell Lymphoma
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Published on: March 30, 2018

Marginal zone lymphoma.

Miguel A Piris1, Alberto Arribas, Manuela Mollejo

  • 1Servicio de Anatomía Patológica, Hospital Universitario Marqués de Valdecilla, Santander, Hospital Virgen de la Salud, Toledo, Spain. mapiris@cnio.es

Seminars in Diagnostic Pathology
|August 17, 2011
PubMed
Summary
This summary is machine-generated.

Marginal zone lymphomas are diverse B-cell neoplasms with distinct features. This review details splenic, nodal, and extranodal (MALT) marginal zone lymphomas, aiding in diagnosis and treatment.

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Analysis of Shear Flow-induced Migration of Murine Marginal Zone B Cells In Vitro
08:31

Analysis of Shear Flow-induced Migration of Murine Marginal Zone B Cells In Vitro

Published on: November 26, 2018

Area of Science:

  • Hematology
  • Oncology
  • Pathology

Background:

  • Marginal zone lymphomas (MZLs) encompass a heterogeneous group of B-cell neoplasms.
  • These lymphomas share some common features but exhibit distinct clinical, immunophenotypic, and molecular characteristics.
  • Understanding these differences is crucial for accurate diagnosis and tailored treatment strategies.

Purpose of the Study:

  • To provide a comprehensive overview of the main features of different marginal zone lymphoma subtypes.
  • To highlight the distinctive aspects of splenic, nodal, and extranodal (mucosa-associated lymphoid tissue) marginal zone lymphomas.
  • To facilitate better recognition and management of these distinct entities.

Main Methods:

  • Literature review of existing studies and clinical data on marginal zone lymphomas.
  • Comparative analysis of morphologic, immunophenotypic, and molecular features.
  • Synthesis of information regarding clinical presentation and treatment recommendations for each subtype.

Main Results:

  • Splenic marginal zone lymphoma (SMZL) typically presents with splenomegaly and specific peripheral blood findings.
  • Nodal marginal zone lymphoma (NMZL) is characterized by lymphadenopathy and distinct immunophenotypic markers.
  • Extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue (MALT lymphoma) arises in various extranodal sites and shows site-specific features.

Conclusions:

  • Marginal zone lymphomas represent a spectrum of diseases requiring subtype-specific evaluation.
  • Accurate classification based on clinical, morphologic, and molecular data is essential for optimal patient outcomes.
  • This review consolidates key information to aid clinicians and researchers in understanding and managing these lymphomas.