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Drug Discovery: Overview

Drug Discovery: Overview

Drug discovery is a multifaceted process involving extensive screening, testing, and optimization of lead compounds to identify potential new drugs for therapeutic use. It combines several approaches, including screening large numbers of natural products, chemical modification of known active molecules, identification of new drug targets, and rational design based on biological mechanisms and drug-receptor structure. These approaches are carried out in both academic research laboratories and...

Issues And Trends In Healthcare Delivery System

Issues And Trends In Healthcare Delivery System

The issues and trends in healthcare delivery are constantly changing. The COVID-19 pandemic is one recent issue that wreaked havoc on healthcare systems, causing a shortage of healthcare workers, high demand for medicines and supplies, and increased medical expenditure due to a lack of insurance. Other issues include rising healthcare costs and care fragmentation.
Cost Containment
Payment for healthcare services has historically promoted adoption of costly and often unnecessary or inefficient...

Drug Delivery: Overview

Drug Delivery: Overview

The selection of a drug's delivery route depends upon its physicochemical properties, including lipid or water solubility and ionization, as well as the therapeutic requirement, such as immediate or sustained effect. These routes can be divided into three primary categories: enteral, parenteral, and topical.
Enteral delivery involves administering drugs directly through swallowing, sublingual placement, or buccal application. Orally administered drugs predominantly navigate the gastrointestinal...

Bioavailability Enhancement: Determination and Conceptual Approaches in Overcoming Bioavailability Problems

Bioavailability Enhancement: Determination and Conceptual Approaches in Overcoming Bioavailability Problems

Bioavailability is a critical pharmacological concept that measures the extent and rate at which an active drug ingredient or therapeutic moiety enters the systemic circulation, remaining unchanged. It's a pivotal factor in determining a drug's efficacy and safety.The Biopharmaceutics Classification System (BCS) plays an essential role in drug development by categorizing drugs into four classes based on their solubility and permeability. This classification aids in understanding drug absorption...

Drug Clearance: Overview

Drug Clearance: Overview

Drug elimination refers to drug removal from the body, either through urine or bile, by the kidneys or liver, respectively. A pharmacokinetic parameter, drug clearance, measures the efficiency of drug removal from the bloodstream within a specific time frame. It is calculated as the rate at which a drug is eliminated from plasma divided by the drug's concentration in plasma.
Drug clearance is not limited to renal excretion but encompasses all organs involved in drug elimination, including the...

Bioavailability Enhancement: Drug Solubility Enhancement

Bioavailability Enhancement: Drug Solubility Enhancement

Bioavailability is a critical factor in determining a drug's effectiveness. It refers to the proportion of a drug that enters the circulation when introduced into the body and is, as a result, able to have an active effect. Enhancing bioavailability is essential for drugs with poor solubility, as it can significantly impact their therapeutic efficacy. Various methods are employed to increase the solubility of drugs, thereby enhancing their bioavailability.Micronization and nanonization are...

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Related Experiment Video

Updated: May 30, 2026

Drug Repurposing Hypothesis Generation Using the "RE:fine Drugs" System

Drug Repurposing Hypothesis Generation Using the "RE:fine Drugs" System

Published on: December 11, 2016

Cloud computing approaches to accelerate drug discovery value chain.

Vibhav Garg¹, Suchir Arora, Chitra Gupta

¹Mascon Global Limited, Healthcare and Life Sciences, 849 Phase -5, Udyog Vihar, Gurgaon, Haryana - 122016, India.

Combinatorial Chemistry & High Throughput Screening

|August 17, 2011

Summary

This summary is machine-generated.

Cloud computing enhances high throughput screening (HTS) data management for drug discovery. This technology offers speed, cost-effectiveness, and flexibility, advancing personalized medicine research.

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Drug Repurposing Hypothesis Generation Using the "RE:fine Drugs" System

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Published on: December 11, 2016

Biosensor-based High Throughput Biopanning and Bioinformatics Analysis Strategy for the Global Validation of Drug-protein Interactions

Biosensor-based High Throughput Biopanning and Bioinformatics Analysis Strategy for the Global Validation of Drug-protein Interactions

Published on: December 1, 2020

Area of Science:

Life Sciences
Computational Biology
Drug Discovery

Background:

High throughput screening (HTS) generates terabytes of data, necessitating advanced storage and analysis solutions.
Traditional infrastructure struggles to meet the computational demands of modern drug discovery pipelines.
Technological advancements have shifted HTS from linear to parallel, system-level screening.

Purpose of the Study:

To explore the transformative potential of cloud computing in managing large-scale HTS data.
To highlight the benefits of on-demand hardware and Software as a Service (SaaS) for drug discovery.
To position cloud computing as a key enabler for personalized medicine.

Main Methods:

Leveraging cloud computing and parallel computing for integrating and analyzing HTS data.
Utilizing on-demand hardware and SaaS delivery models.
Focusing on data management, mining, and analysis for informational tag identification.

Main Results:

Cloud computing offers speed, efficiency, and cost-effectiveness in HTS data processing.
Integration of cloud and parallel computing expands its application in life sciences.
Researchers gain flexibility, allowing focus on scientific objectives rather than infrastructure.

Conclusions:

Cloud computing, particularly 'Discovery-Cloud', is poised to revolutionize drug discovery and clinical development data management.
This technology supports the vision of personalized medicine by enabling efficient handling of complex datasets.
The adoption of cloud solutions provides researchers with essential computational power and flexibility.