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Measurement of NT-proBNP with LOCI technology in heart failure patients
D Gruson1, Sylvie A Ahn, Thibault Lepoutre
1Pôle de recherche en Endocrinologie, Diabète et Nutrition, Institut de Recherche Expérimentale et Clinique, Cliniques Universitaires St-Luc and Université Catholique de Louvain, Brussels, Belgium. damien.gruson@uclouvain.be
Objectives:
The aim of our study was to determine NT-proBNP concentrations in heart failure (HF) patients with a luminescent oxygen channeling immunoassay (LOCI).
Design And Methods:
Seventy HF patients were enrolled. NT-proBNP levels were measured with LOCI method and compared to a reference NT-proBNP assay.
Results:
LOCI NT-proBNP levels were significantly correlated with the reference NT-proBNP assay and were related to HF severity.
Conclusions:
LOCI assay demonstrates performances close to the comparative assay for NT-proBNP testing and allows a significant reduction of the time of analysis.

