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Updated: May 30, 2026
MicroRNA In situ Hybridization for Formalin Fixed Kidney Tissues
Published on: November 30, 2013
[Abnormal expression and significance of MIR-184 in human renal carcinoma]
Hui-min Leng1, Wei-ping Qian, Liang Zhou
1Department of Reproductive Medicine, Peking University Shenzhen Hospital, Shenzhen 518036, China.
Objective:
To explore the role of microRNA-184(MIR-184) in the development of renal cell carcinoma(RCC).
Methods:
The expressions of MIR-184 in 51 patients with RCC Investigated, normal adjacent tissues (ADTs) matched by fluorescence quantitative PCR technology (RT-qPCR) and the correlations analyzed between MIR-184 expression and the age, gender and clinical stage of RCC patients.
Results:
The average expression of MIR-184 in RCC was -14.664 6 ± 5.362 4, while that in ADTs was -10.408 7 ± 3.482 7(P<0.01). Bounded with the MIR-184 expression in RCC, patients were divided into lower-expression group and higher-expression group. Meanwhile, the RCC patients were divided into three groups according to the age, gender and clinical stage of the patients. Chi-square statistical analysis showed that the expression level of MIR-184 was not significantly correlated with the patient's age, gender and clinical stage (respectively: P>0.03, P>0.99, P>0.03).
Conclusion:
MIR-184 in RCC was significantly lower than that in ADTs, which may have potential significance in the occurrence and development of RCC.
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