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High-throughput Quantitative Real-time RT-PCR Assay for Determining Expression Profiles of Types I and III Interferon Subtypes
Published on: March 24, 2015
[Fish interferon response and its molecular regulation: a review]
1State Key Laboratory of Freshwater Ecology and Biotechnology, Institute of Hydrobiology, Chinese Academy of Sciences, Wuhan 430072, China. ybzhang@ihb.ac.cn
Sheng Wu Gong Cheng Xue Bao = Chinese Journal of Biotechnology
|August 18, 2011
Summary
Fish possess a unique interferon antiviral defense system similar to mammals, but with distinct genetic features. This review explores recent advancements in understanding fish interferon response and its molecular mechanisms.
Area of Science:
- Immunology
- Virology
- Genetics
Context:
- The interferon response is crucial for host defense against viral infections.
- Significant progress has been made in understanding fish innate immunity and antiviral responses.
- Fish interferon (IFN) antiviral systems share similarities with mammalian systems.
Purpose:
- To review recent advancements in fish interferon response and its molecular mechanisms.
- To address the complexities and debates surrounding fish interferon gene nomenclature.
- To highlight unique aspects of fish interferon antiviral response.
Summary:
- Fish exhibit an interferon antiviral system analogous to mammals, involving identified antiviral genes.
- Fish virus-induced interferon genes possess introns, similar to type III interferons, yet encode type I-like proteins.
- This genetic characteristic complicates evolutionary understanding and fuels debate on fish interferon nomenclature.
Impact:
- Provides a comprehensive overview of fish interferon antiviral mechanisms.
- Clarifies the evolutionary context and nomenclature of fish interferon genes.
- Enhances understanding of vertebrate interferon evolution and innate immunity.
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